Results 251 to 260 of about 120,581 (311)

Minocycline Treatment Improves Memory and Reduces Anxiety by Lowering Levels of Brain Amyloid Precursor Protein and Indoleamine 2,3-Dioxygenase in a Rat Model of Streptozotocin-Induced Alzheimer's Disease. [PDF]

Int J Mol Sci
Świątek G, Nowakowska-Gołacka J, Słomińska-Wojewódzka M, Glac W, Harackiewicz O, Kurowska-Rucińska E, Wrona D.   +6 more
europepmc   +1 more source

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

Familial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors. [PDF]

J Biol Chem
Tavalin SJ.
europepmc   +1 more source

Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss. [PDF]

Alzheimers Dement
Yeapuri P, Machhi J, Foster EG, Kadry R, Bhattarai S, Lu Y, Sil S, Sapkota R, Srivastava S, Kumar M, Ikezu T, Poluektova LY, Gendelman HE, Mosley RL.   +13 more
europepmc   +1 more source

The reciprocal relationship between amyloid precursor protein and mitochondrial function. [PDF]

J Neurochem
Strope TA, Wilkins HM.
europepmc   +1 more source

FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer's disease through the ubiquitination-dependent degradation of amyloid precursor protein. [PDF]

Biomark Res
Qu L, Tang Y, Wu J, Yun X, Lo HH, Song L, Wang X, Wang H, Zhang R, Liu M, Wang C, Ng JPL, Fu X, Wong IN, Wong VKW, Law BYK.   +15 more
europepmc   +1 more source

Correction to "Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss". [PDF]

Alzheimers Dement
europepmc   +1 more source