Results 271 to 280 of about 120,581 (311)

Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
D, Schubert, G, Cole, T, Saitoh, T, Oltersdorf   +3 more
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Amyloid precursor protein in Alzheimer's disease

2023
Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity.
Rupesh, Maurya, Gargi, Bhattacharjee, Khushal, Khambhati, Nisarg, Gohil, Priyanka, Singh, Indra, Mani, Dinh-Toi, Chu, Suresh, Ramakrishna, Pau-Loke, Show, Vijai, Singh   +9 more
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Amyloid Precursor Protein Is Found in Lysosomes

Gerontology, 2009
The major component of Alzheimer’s disease amyloid is a small polypeptide referred as the amyloid β protein, which is derived from a larger precursor, amyloid precursor protein (APP). Cell fractionation and immunological studies on the APP molecule indicate that APP is localized either in the neuron and astrocyte and that the molecule is recovered from
K, Tagawa, M, Yazaki, T, Kinouchi, K, Maruyama, H, Sorimachi, T, Tsuchiya, K, Suzuki, S, Ishiura   +7 more
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The pharmacology of amyloid precursor protein processing

Experimental Gerontology, 2003
The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood.
RACCHI, MARCO, GOVONI, STEFANO
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The Functions of the Amyloid Precursor Protein Gene

Reviews in the Neurosciences, 2001
The amyloid precursor protein (APP) gene and its protein products have multiple functions in the central nervous system and fulfil criteria as neuractive peptides: presence, release and identity of action. There is increased understanding of the role of secretases (proteases) in the metabolism of APP and the production of its peptide fragments. The APP
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Not just amyloid: physiological functions of the amyloid precursor protein family

Nature Reviews Neuroscience, 2017
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood.
Ulrike C, Müller, Thomas, Deller, Martin, Korte   +2 more
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Neurite outgrowth and the amyloid protein precursor

Neurobiology of Aging, 1989
Neurite outgrowth in Alzheimer's disease may well be a multifactorial phenomenon. Recent evidence suggests possible roles for the protease inhibitor domain of the 751 amino acid amyloid precursor protein (APP), as well as for the 695 amino acid APP.
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Genetics of the Alzheimer Amyloid Protein Precursor

1990
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of memory, reasoning, orientation, and judgment (Katzman, 1983). AD generally occurs as a sporadic disorder of unknown cause. However, a proportion of cases, which have been termed familial Alzheimer’s disease (FAD), are caused by a genetic defect that is
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AMYLOID PRECURSOR PROTEIN

Alzheimer Disease & Associated Disorders, 1988
G. PERRY, S. LIPPHARDT, P. MULVIHILL, M. KANCHERLA, L. AUTILIO-GAMBETTI, P. GAMBETTI, S. SHARMA, L. MAGGIORA, J. CORNETTE, T. LOBL, B. GREENBERG   +10 more
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Amyloid Precursor Protein

2007
S.J. Enna, David B. Bylund
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