Results 201 to 210 of about 82,488 (290)

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Familial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors. [PDF]

J Biol Chem
Tavalin SJ.
europepmc   +1 more source

Top‐Down Proteomics: Why and When?

PROTEOMICS, EarlyView.
ABSTRACT Manifold biological processes at all levels of transcription and translation can lead to the formation of a high number of different protein species (i.e., proteoforms), which outnumber the sequences encoded in the genome by far. Due to the large number of protein molecules formed in this way, which span an enormous range of different ...
Philipp T. Kaulich, Andreas Tholey
wiley   +1 more source

Activity of α‐Secretase as the Common Final Effector of Protein Kinase C‐Dependent and ‐Independent Modulation of Amyloid Precursor Protein Metabolism [PDF]

, 1999
Marco Racchi, Daniela C. Solano, M. Sironi, Stefano Govoni   +3 more
openalex   +1 more source

Trusting Your Gut When it Comes to the Origin of Parkinson's Disease

Movement Disorders, EarlyView.
Per Borghammer, Nathalie Van Den Berge, Casper Skjærbæk, Jacob Horsager   +3 more
wiley   +1 more source

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source

Cellular and molecular basis of beta-amyloid precursor protein metabolism [PDF]

, 1998
Huaxi Xu
openalex   +1 more source

KLVFF Functionalized Graphene Oxide for Aβ42 Peptide Electrical Detection: A Promising Nanomaterial for the Development of Alzheimer's Disease Diagnostic Devices

Small, EarlyView.
An electrical transduction sensor (GO@peg4‐KLVFF) deposited by DEP, based on graphene oxide, suitably functionalized for the detection of Aβ42, one of the main Alzheimer's disease biomarkers is proposed. The detection activity is established on the measurement of the electrical resistance change induced by the specific interaction occurring between the
Viviana Scuderi, Rita Turnaturi, Simona Filice, Simona Crispi, Giuseppe Di Natale, Giuseppina Sabatino, Damiano Ricciarelli, Giuseppe Fisicaro, Giuseppe Pappalardo, Antonino La Magna, Silvia Scalese   +10 more
wiley   +1 more source

Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi. [PDF]

Chem Res Toxicol
Ford M, Thomson PJ, Lister A, Snoeys J, Leclercq L, Cuyckens F, Naisbitt DJ, Meng X.   +7 more
europepmc   +1 more source

Nose‐to‐Brain Delivery of Acyl‐Ghrelin Peptide Gold Nanoconjugates for Treatment of Neurodegenerative Diseases

Small, EarlyView.
Intranasal delivery of acyl‐ghrelin using gold nanorods (AuNRs) is investigated as a strategy for treating neurodegenerative diseases. Acyl‐ghrelin is conjugated to AuNRs under optimized conditions that preserve its bioactivity and prevent nanoparticle cross‐linking.
Shunping Han, Rifka N. Utami, Yue Qin, Revadee Liam‐Or, Jemeen Sreedharan, Jeffrey S. Davies, Khuloud T. Al‐Jamal   +6 more
wiley   +1 more source