Results 211 to 220 of about 82,488 (290)

The reciprocal relationship between amyloid precursor protein and mitochondrial function. [PDF]

J Neurochem
Strope TA, Wilkins HM.
europepmc   +1 more source

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

, 1997
Kelly Johnson‐Wood, M. Lee, Ruth Motter, Kang Hu, Grace Gordon, Robin Barbour, Karen Khan, Marcia N. Gordon, Hua Tan, Dora Games, Ivan Lieberburg, Dale Schenk, Peter Seubert, Lisa McConlogue   +13 more
openalex   +1 more source

2D Materials: From Design and Synthesis to Applications in Electrical and Electrochemical Biosensors

Small, EarlyView.
Various types of 2D materials, encompassing all potential candidates to date, are examined alongside their synthetic methods and functionalization strategies for bioreceptor immobilization. This review highlights approaches for designing and scaling up these materials to enable cost‐effective electrical and electrochemical biosensing applications ...
Masud, Jaeyoon Song, Falguni Ahmed, Jinsik Kim   +3 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Correction to "Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss". [PDF]

Alzheimers Dement
europepmc   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer's disease through the ubiquitination-dependent degradation of amyloid precursor protein. [PDF]

Biomark Res
Qu L, Tang Y, Wu J, Yun X, Lo HH, Song L, Wang X, Wang H, Zhang R, Liu M, Wang C, Ng JPL, Fu X, Wong IN, Wong VKW, Law BYK.   +15 more
europepmc   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source

Expression of Concern: Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce β-amyloid in Alzheimer's disease. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells

Aging Cell, EarlyView.
Healthy RPE cells produce AMPs and AMP precursors, including amyloid precursor protein (APP) and chemerin, and protect the neuroretina from blood‐borne pathogens and maintain homeostasis. When RPE cells undergo senescence, the antibacterial activity declines, and APP undergoes amylogenesis, leading to Aβ deposition.
Jian Liu, Caijiao Yi, Jinyan Qi, Xuexue Cui, Xiangling Yuan, Wen Deng, Mei Chen, Heping Xu   +7 more
wiley   +1 more source