Results 271 to 280 of about 82,488 (290)

Physiology and pharmacology of amyloid precursor protein

Pharmacology & Therapeutics, 2022
Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in the brains of individuals with Alzheimer's disease (AD)-related pathologies. Aβ has been extensively investigated since the amyloid hypothesis in AD was proposed.
Yoonsuk, Cho, Han-Gyu, Bae, Eitan, Okun, Thiruma V, Arumugam, Dong-Gyu, Jo   +4 more
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Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
Tsunao Saitoh, Tilman Oltersdorf, David Schubert, Greg M. Cole   +3 more
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β-Amyloid precursor is a PEST protein

Biochemical and Biophysical Research Communications, 1989
The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins.
Robert Siman, Greg R. Christoph
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Amyloid Precursor Protein Is Found in Lysosomes

Gerontology, 1993
The major component of Alzheimer's disease amyloid is a small polypeptide referred as the amyloid beta protein, which is derived from a larger precursor, amyloid precursor protein (APP). Cell fractionation and immunological studies on the APP molecule indicate that APP is localized either in the neuron and astrocyte and that the molecule is recovered ...
Shoichi Ishiura, Hiroyuki Sorimachi, Koichi Suzuki, Madoka Yazaki, Kazuhiko Tagawa, Tadatoshi Kinouchi, Kei Maruyama, Takahide Tsuchiya   +7 more
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Not just amyloid: physiological functions of the amyloid precursor protein family [PDF]

Nature Reviews Neuroscience, 2017
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood.
Thomas Deller, Martin Korte, Ulrike Müller   +2 more
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Amyloid precursor protein in Alzheimer's disease

2023
Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity.
Rupesh, Maurya, Gargi, Bhattacharjee, Khushal, Khambhati, Nisarg, Gohil, Priyanka, Singh, Indra, Mani, Dinh-Toi, Chu, Suresh, Ramakrishna, Pau-Loke, Show, Vijai, Singh   +9 more
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Regulation of Amyloid Precursor Protein Cleavage

Journal of Neurochemistry, 1999
Abstract : Multiple lines of evidence suggest that increased production and/or deposition of the β‐amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's disease. A growing list of neuro‐transmitters, growth factors, cytokines, and hormones have been shown to regulate amyloid precursor protein processing.
Peter B. Reiner, Julia Mills
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The Functions of the Amyloid Precursor Protein Gene

Reviews in the Neurosciences, 2001
The amyloid precursor protein (APP) gene and its protein products have multiple functions in the central nervous system and fulfil criteria as neuractive peptides: presence, release and identity of action. There is increased understanding of the role of secretases (proteases) in the metabolism of APP and the production of its peptide fragments. The APP
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MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2

Brain Research, 2012
Increased expression of the amyloid precursor protein (APP) is a crucial risk factor of Alzheimer's disease (AD). Amyloid precursor-like protein 2 (APLP2), a homologue of APP, is also suggested to participate in AD pathogenesis. Accumulating evidence suggest the regulatory role of microRNA on AD-related genes.
Hua Zhu, Chunmei Ma, Chuan Qin, Yanfeng Xu, Ying Liu, Chunlian Liang, Lan Huang, Wei Deng   +7 more
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Neurite outgrowth and the amyloid protein precursor

Neurobiology of Aging, 1989
Neurite outgrowth in Alzheimer's disease may well be a multifactorial phenomenon. Recent evidence suggests possible roles for the protease inhibitor domain of the 751 amino acid amyloid precursor protein (APP), as well as for the 695 amino acid APP.
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