Results 281 to 290 of about 343,599 (390)

Relationship between age and severity of cognitive impairment at diagnosis for early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
INTRODUCTION Recent work has identified unique cognitive profiles for early‐onset Alzheimer's disease (EOAD) relative to late‐onset Alzheimer's disease (LOAD), however, examination has been limited in determining whether the association between age and cognitive severity at presentation also differs across conditions.
Dustin B. Hammers, Ani Eloyan, Maryanne Thangarajah, Alexander Taurone, Sujuan Gao, Laurel Beckett, Kala Kirby, Jeffrey L. Dage, Kelly Nudelman, Paul Aisen, Rema Reman, Prashanthi Vemuri, Renaud La Joie, Alexandra Touroutoglou, Alireza Atri, David Clark, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Kyle Womack, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Ian Grant, Emily Rogalski, Erik C. B. Johnson, Steven Salloway, Sharon J. Sha, Raymond Scott Turner, Thomas S. Wingo, David A. Wolk, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova, LEADS Consortium, for the Alzheimer's Disease Neuroimaging Initiative   +40 more
wiley   +1 more source

Developmental deletion of amyloid precursor protein precludes transcriptional and proteomic responses to brain injury. [PDF]

Alzheimers Dement
Lacovich V, Čarna M, Novotný SJ, Wang S, Texlová K, Kovačovicova KL, Dragišić N, Havas D, Head BP, Geda YE, Limbäck-Stokin C, Stokin GB.   +11 more
europepmc   +1 more source

Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease

, 2017
Patricia L.A. Leighton
openalex   +1 more source

Amyloid Alpha Precursor Protein Measurement [PDF]

, 2020
openaire   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Supplementary Figure S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity [PDF]

Mohamed Faisal Kassir, Han Gyul Lee, Natalia V. Oleinik, Wyatt Wofford, Chase Walton, Firdevs Cansu Atilgan, Alhaji H. Janneh, Paramita Chakraborty, Kübra Çalışır, Elif Perçin, Silvia G. Vaena, Kalyani Sonawane, Ashish A. Deshmukh, Narayan R. Bhat, Kumar Sambamurti, Önder Albayram, Özgür Şahin, Shikhar Mehrotra, Besim Öğretmen   +18 more
openalex   +1 more source

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

Potential Anti‐Aging Effects of a Dietary Supplement From the Algal‐Derived Omega‐3 DHA in Aged SAMP 8 Mice

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Algal‐derived Omega‐3 DHA supplementation exerts significant anti‐aging and neuroprotective effects in SAMP8 mice. Algal Omega‐3 DHA effectively mitigates age‐related cognitive decline, enhances antioxidant defenses, and extends lifespan. Algal‐derived Omega‐3 DHA supplementation enhances cognitive function, attenuates oxidative stress, and reduces ...
Ming‐Yu Chou, I‐Hung Lin, Chia‐Jung Chen, Ting‐Jian Guo, Che‐An Lin, Dao‐Na Yang, Po‐Hsien Li, Yu‐Chen Li, Mei‐Due Yang, Chieh‐Chang Tien, Ruei‐Ze Lin, Ching‐Hsin Chi, Shih‐Yi Wang, Ming‐Fu Wang   +13 more
wiley   +1 more source