Results 21 to 30 of about 82,488 (290)

Amyloid precursor protein and neural development [PDF]

Development, 2014
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests
Bassem A. Hassan, Maya Nicolas
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Amyloid precursor protein processing and bioenergetics [PDF]

Brain Research Bulletin, 2017
The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing
Heather M. Wilkins, Russell H. Swerdlow
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Interactions between amyloid, amyloid precursor protein, and mitochondria

Biochemical Society Transactions, 2023
Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria.
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Identification of Ameloblastin as an Amyloid Precursor Protein of Amyloid-Producing Ameloblastoma in Dogs and Cats

Veterinary Sciences, 2023
Amyloid-producing ameloblastoma (APAB) is characterized by abundant amyloid deposits in ameloblastoma, but the amyloid precursor protein is unknown.
Niki Sedghi Masoud, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, Tomoaki Murakami   +5 more
doaj   +1 more source

Amyloid precursor protein in pancreatic islets [PDF]

Journal of Endocrinology, 2017
The amyloid precursor protein (APP) has been extensively investigated for its role in the production of amyloid beta (Aβ), a plaque-forming peptide in Alzheimer’s disease (AD). Epidemiological evidence suggests type 2 diabetes is a risk factor for AD. The pancreas is an essential regulator of blood glucose levels through the secretion of the hormones ...
Colin K. Combs, Kendra L. Puig, Joshua A. Kulas   +2 more
openaire   +3 more sources

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

PLoS ONE, 2016
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a ...
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper   +7 more
doaj   +1 more source

Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma

Frontiers in Psychiatry, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests.
Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Qiu Li, Qiu Li, Qiu Li, Qiu Li, Bin Peng, Yupeng Cun, Yupeng Cun, Yupeng Cun, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Yang Yu, Yang Yu, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Qiongli Fan, Yuping Zhang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Li Chen, Li Chen, Li Chen, Li Chen, Li Chen   +66 more
doaj   +1 more source

The amyloid precursor protein is a conserved Wnt receptor

eLife, 2021
The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be.
Tingting Zhang, Tingting Zhang, Marie-Claude Potier, Annelies Claeys, Maya Nicolas, Tengyuan Liu, Tengyuan Liu, Lee G. Fradkin, Iveta M. Petrova, Bart De Strooper, Bart De Strooper, Bassem A. Hassan, Lydie Boussicault, Heather C. Rice, Alessia Soldano   +14 more
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FMRP mediates mGluR5-dependent translation of amyloid precursor protein. [PDF]

PLoS Biology, 2007
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission.
Cara J Westmark, James S Malter
doaj   +1 more source

Dual Action of Memantine in Alzheimer Disease: A Hypothesis

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-
Tzong-Yuan Wu, Chih-Ping Chen
doaj   +1 more source