Results 21 to 30 of about 343,599 (390)

Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]

, 2006
Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core   +1 more source

Identification of Ameloblastin as an Amyloid Precursor Protein of Amyloid-Producing Ameloblastoma in Dogs and Cats

Veterinary Sciences, 2023
Amyloid-producing ameloblastoma (APAB) is characterized by abundant amyloid deposits in ameloblastoma, but the amyloid precursor protein is unknown.
Niki Sedghi Masoud, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, Tomoaki Murakami   +5 more
doaj   +1 more source

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]

, 2008
Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Czirr, Eva, Esselmann, Hermann, Leuchtenberger, Stefanie, Lichtenthaler, Stefan F., Maler, Juan, Ness, Julia, Pietrzik, Claus U., Weggen, Sascha, Wiltfang, Jens   +8 more
core   +1 more source

Crystal structure of monomeric human β-2- microglobulin reveals clues to its amyloidogenic properties [PDF]

, 2002
Dissociation of human β-2-microglobulin (β(2)m) from the heavy chain of the class I HLA complex is a critical first step in the formation of amyloid fibrils from this protein.
A. P. Kalverda, Adams, Becker, Bellotti, Berman, Booth, C. H. Trinh, Collaborative Computational Project Number, Connors, D. P. Smith, Delaglio, Esposito, Floege, Hoshino, Kabsch, Kad, Khan, Khurana, Laskowski, Linke, McParland, Merritt, Morgan, Ohhashi, Okon, Richardson, S. E. Radford, S. E. V. Phillips, Saper, Smith, Verdone, Wang   +31 more
core   +2 more sources

Data on thrombotic ischemic lesions in the presence or absence of amyloid ß-protein precursor or its homolog amyloid precursor-like protein-2 in mice

Data in Brief, 2016
Amyloid ß-protein precursor (AßPP) and amyloid precursor-like protein-2 (APLP2) are potent inhibitors of thrombosis, see related article “The influence of the amyloid ß-protein and its precursor in modulating cerebral thrombosis” (Van Nostrand, 2016) [1].
Feng Xu, William E. Van Nostrand
doaj   +1 more source

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. [PDF]

PLoS ONE, 2011
BACKGROUND: sAPPα released after α secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done. Two domains involved in this function
Stéphanie Chasseigneaux, Levent Dinc, Christiane Rose, Claude Chabret, Fanny Coulpier, Piotr Topilko, Gweltas Mauger, Bernadette Allinquant   +7 more
doaj   +1 more source

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins [PDF]

, 2018
Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways.
Baglivo, I, Coletta, M, D'Abrosca, G, De Stefano, M, Fattorusso, R., Gianni, S, Isernia, C, Majewska, R, Malgieri, G, Milardi, D, Palmieri, M, Pedone, Em, Pedone, Pv, Pirone, L, Russo, L, Sciacca, Mfm, Sivo, V, Tatè, R, Toto, A   +18 more
core   +2 more sources

Interactions between amyloid, amyloid precursor protein, and mitochondria

Biochemical Society Transactions, 2023
Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria.
openaire   +2 more sources

Amyloid precursor protein induces reactive astrogliosis

Acta Physiologica, 2023
AbstractAimAstrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role
Gretsen Velezmoro Jauregui, Dragana Vukić, Isaac G. Onyango, Carlos Arias, Jan S. Novotný, Kateřina Texlová, Shanshan Wang, Kristina Locker Kovačovicova, Natalie Polakova, Jana Zelinkova, Maria Čarna, Valentina Lacovich Strašil, Brian P. Head, Daniel Havas, Martin Mistrik, Robert Zorec, Alexei Verkhratsky, Liam Keegan, Mary O’Connel, Robert Rissman, Gorazd B. Stokin   +20 more
openaire   +6 more sources