Results 31 to 40 of about 343,599 (390)

Amyloid precursor protein modulates β-catenin degradation

Journal of Neuroinflammation, 2007
Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj   +1 more source

A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils [PDF]

, 2008
Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases.
Jahn, T.R., Radford, S.E., Tennent, G.A.
core   +2 more sources

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

PLoS ONE, 2016
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a ...
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper   +7 more
doaj   +1 more source

Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

Molecules, 2022
The amyloid hypothesis of Alzheimer’s disease has long been the predominant theory, suggesting that Alzheimer’s disease is caused by the accumulation of amyloid beta protein (Aβ) in the brain, leading to neuronal toxicity in the central nervous system ...
Chen Ma, Fenfang Hong, Shulong Yang
doaj   +1 more source

Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma

Frontiers in Psychiatry, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests.
Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Qiu Li, Qiu Li, Qiu Li, Qiu Li, Bin Peng, Yupeng Cun, Yupeng Cun, Yupeng Cun, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Yang Yu, Yang Yu, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Qiongli Fan, Yuping Zhang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Li Chen, Li Chen, Li Chen, Li Chen, Li Chen   +66 more
doaj   +1 more source

Alzheimer's disease and HIV associated dementia related genes: I. location and function. [PDF]

, 2008
Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias.
Chiappelli, Francesco, Kayathri, Rajarathinam, Levine, Andrew, Minagar, Alireza, Rodriguez, Hector E, Shapshak, Paul   +5 more
core   +3 more sources

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

Neurobiology of Disease, 2005
Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein.
Christoph Köhler, Ulrich Ebert, Karlheinz Baumann, Hannsjörg Schröder   +3 more
doaj   +1 more source

FMRP mediates mGluR5-dependent translation of amyloid precursor protein. [PDF]

PLoS Biology, 2007
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission.
Cara J Westmark, James S Malter
doaj   +1 more source

APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]

, 1993
Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Beyreuther, K., Dichgans, Martin, König, G., Masters, C. L., Mönning, U., Sandbrink, R.   +5 more
core   +1 more source

Amyloid precursor protein in pancreatic islets [PDF]

Journal of Endocrinology, 2017
The amyloid precursor protein (APP) has been extensively investigated for its role in the production of amyloid beta (Aβ), a plaque-forming peptide in Alzheimer’s disease (AD). Epidemiological evidence suggests type 2 diabetes is a risk factor for AD. The pancreas is an essential regulator of blood glucose levels through the secretion of the hormones ...
Joshua A, Kulas, Kendra L, Puig, Colin K, Combs   +2 more
openaire   +2 more sources