Results 121 to 130 of about 14,023 (271)

CD74 interacts with APP and suppresses the production of Aβ [PDF]

, 2009
Background Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of β amyloid (Aβ) peptides. Aβ is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing by β-secretase and γ-secretase ...
D'Adamio Luciano, Matsuda Yukiko, Matsuda Shuji   +2 more
core   +1 more source

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein [PDF]

, 2008
Vivian Hook, Mark S. Kindy, Gregory Hook
openalex   +1 more source

Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation [PDF]

, 2023
István Hajdú, Barbara M. Végh, András Szilágyi, Péter Závodszky   +3 more
openalex   +1 more source

Effects of hypertension and anti-hypertensive treatment on Aβ plaque load, Aβ–synthesising and –degrading enzymes in frontal cortex [PDF]

, 2016
Epidemiological data associate hypertension with a predisposition to Alzheimer’s disease (AD), and a number of postmortem and in vivo studies also demonstrate that hypertension increases amyloid-β (Aβ) pathology.
Ashby, Emma L, Kehoe, Patrick Gavin, Love, Seth, Miners, J S   +3 more
core   +2 more sources

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment [PDF]

, 2010
Carrie McAllister, Jiangang Long, Adrienne Bowers, Aaron Walker, Philip Cao, Shin-Ichiro Honda, Nobuhiro Harada, Matthias Staufenbiel, Yong Shen, Rena Li   +9 more
openalex   +1 more source

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

PLoS ONE, 2014
Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD). APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C99) impairs processive cleavage by γ-secretase increasing ...
Jung J.I., Premraj S., Cruz P.E., Ladd T.B., Kwak Y., Koo E.H., Felsenstein K.M., Golde T.E., Ran Y.   +8 more
openaire   +4 more sources

Secretory phospholipase A2 type III enhances α-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity

Journal of Lipid Research, 2010
In the non-amyloidogenic pathway, amyloid precursor protein (APP) is cleaved by α-secretases to produce α-secretase-cleaved soluble APP (sAPPα) with neuroprotective and neurotrophic properties; therefore, enhancing the non-amyloidogenic pathway has been ...
Xiaoguang Yang, Wenwen Sheng, Yan He, Jiankun Cui, Mark A. Haidekker, Grace Y. Sun, James C-M. Lee   +6 more
doaj   +1 more source

Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein [PDF]

, 2010
Can Zhang, Andrew Browne, Daniel D. Child, Jason DiVito, Jesse A. Stevenson, Rudolph E. Tanzi   +5 more
openalex   +1 more source

Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10 [PDF]

, 2001
Elvira Lopez‐Perez, Yue Zhang, Stuart J. Frank, John W.M. Creemers, Nabil G. Seidah, Frédéric Checler   +5 more
openalex   +1 more source

Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production [PDF]

, 2007
Xiangyuan He, Kathleen Cooley, Charlotte Hiu-Yan Chung, Nassrin Dashti, Jordan Tang   +4 more
openalex   +1 more source