Results 101 to 110 of about 14,107 (263)

Human iPSC‐derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by disrupted excitatory–inhibitory (E:I) balance and impaired synaptic function, yet current treatments fail to repair these fundamental circuit impairments. METHODS Human induced pluripotent stem cell‐derived post‐mitotic medial ganglionic eminence‐originated inhibitory neurons (MGE‐pINs)
Xinzhe Zhang, Gaojie Wang, Haodong Chen, Ye Sun, Ziteng Wangliu, Lijing Wang, Miao Sun, Qing Liu, Xue Zhang   +8 more
wiley   +1 more source

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism [PDF]

, 2017
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer’s disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the “post-GWAS” era.
Cruchaga, Carlos, et al,, Goate, Alison M   +2 more
core   +4 more sources

Role of membrane biophysics in Alzheimer\u27s–related cell pathways [PDF]

, 2015
Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and
Bungart, Brittani L, Lee, James C-M., Yang, Xiaoguang, Zhu, Donghui, Zhumadilov, Zhaxybay   +4 more
core   +8 more sources

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease

BMC Neuroscience, 2019
Background Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therapeutic targets to limit disease ...
Zein Al-Atrache, Danielle B. Lopez, Susan T. Hingley, Denah M. Appelt   +3 more
doaj   +1 more source

Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice. [PDF]

PLoS ONE, 2014
Coincident with the expanding population of aged people, the incidence of Alzheimer disease (AD) is rapidly increasing in most advanced countries. At present, no effective prophylactics are available. Among several pathological mechanisms proposed for AD,
Norio Sasaoka, Megumi Sakamoto, Shoko Kanemori, Michiru Kan, Chihiro Tsukano, Yoshiji Takemoto, Akira Kakizuka   +6 more
doaj   +1 more source

Single-Cell Detection of Secreted A  and sAPP  from Human IPSC-Derived Neurons and Astrocytes [PDF]

, 2015
Secreted factors play a central role in normal and pathological processes in every tissue in the body. The brain is composed of a highly complex milieu of different cell types and few methods exist that can identify which individual cells in a complex ...
De Jager, P. L., Gierahn, Todd Michael, Liao, M.-C., Love, John C, Muratore, C. R., Srikanth, P., Sullivan, S. E., Young-Pearse, T. L.   +7 more
core   +1 more source

AS1842856 Reduces β‐Amyloid Burden via Inhibiting PLA2G4A‐Mediated Lysosomal Dysfunction in APP/PS1 Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
AS1842856 reduces intracellular levels of GSK3α/β by binding to them and promoting their exocytosis. This reduction leads to diminished GSK3β‐mediated activation of NF‐κB, resulting in decreased transcription of PLA2G4A and reduced lysosomal damage. Ultimately, this enhances lysosomal degradation of Aβ, lowering Aβ load in APP/PS1 mice.
Da‐Long He, Zheng Wu, Rong‐Jun Jia, Ting‐Yao Wu, Yi‐Min Qiu, Yong‐Gang Fan   +5 more
wiley   +1 more source

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells. [PDF]

PLoS ONE, 2016
Amyloid-β (Aβ), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from sequential proteolytic cleavage of amyloid protein precursor (APP) by secretases.
Xia-Fei Wang, Dong-Xin Liu, Yue Liang, Li-Li Xing, Wen-Hui Zhao, Xiao-Xue Qin, De-Shu Shang, Bo Li, Wen-Gang Fang, Liu Cao, Wei-Dong Zhao, Yu-Hua Chen   +11 more
doaj   +1 more source

Bryostatin-1 vs. TPPB: Dose-Dependent APP Processing and PKC-α, -δ, and -ε Isoform Activation in SH-SY5Y Neuronal Cells [PDF]

, 2012
Activation of the α-secretase processing pathway of amyloid precursor protein (APP) is recognized as an important mechanism which diverts APP processing from production of beta-amyloid (Aβ) to non toxic sAPPα, decreasing Alzheimer’s disease (AD) plaque ...
J. S. Alexander, L. Schrott, P. Yi, T. P. Castor   +3 more
core   +1 more source

ADAM10‐Mediated Proteolytic Remodelling of Signalling and Adhesion Proteins on Brain Cell‐Derived Small Extracellular Vesicles

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Proteases are common components of extracellular vesicles (EVs), yet the extent and functional relevance of ongoing proteolytic activity on EV surfaces remain largely unexplored. Such activity could significantly influence EV function and identity, with likely implications for EV‐mediated signalling, recipient cell targeting, cargo delivery ...
Christopher C. Reimann, Hermann C. Altmeppen, Tomas Koudelka, Michaela Schweizer, Andreas Tholey, Behnam Mohammadi, Julia Bär, Lesley Cheng, Markus Glatzel, Marina Mikhaylova, Andrew F. Hill   +10 more
wiley   +1 more source