Results 81 to 90 of about 14,107 (263)

Nonspecificity of Binding of γ-Secretase Modulators to the Amyloid Precursor Protein [PDF]

Biochemistry, 2009
Evidence that certain gamma-secretase modulators (GSMs) target the 99-residue C-terminal domain (C99) of the amyloid precursor protein, a substrate of gamma-secretase, but not the protease complex itself has been presented [Kukar, T. L., et al. (2008) Nature 453, 925-929].
Andrew J, Beel, Paul, Barrett, Paul D, Schnier, Stephen A, Hitchcock, Dhanashri, Bagal, Charles R, Sanders, John B, Jordan   +6 more
openaire   +2 more sources

The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

Neurobiology of Disease, 2016
The processing of amyloid precursor protein (APP) into β-amyloid peptide (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and trafficking dysregulations of APP and its secretases contribute significantly to altered APP processing. Here
Miao Sun, Suwaiba Z. Asghar, Huaye Zhang
doaj   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Phosphate‐ and pH‐dependent self‐assembly of recombinant spider silk proteins

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The process of molecular self‐assembly is an omnipresent mechanism in nature to generate a variety of efficient and functional hierarchical architectures, and inspires tailored material design and development. Thereby, self‐assembly is based on a controlled interplay and association of monomers into highly ordered structures triggered by ...
Vanessa T. Trossmann, Veronika Hovanová, Tim Schiller, Martin Humenik, Erik Sedlák, Thomas R. Scheibel   +5 more
wiley   +1 more source

Intracellular trafficking of the β-secretase and processing of amyloid precursor protein [PDF]

IUBMB Life, 2011
The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the β-amyloid peptide (Aβ) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Aβ is derived from the proteolytic processing of the amyloid precursor protein (APP).
Pei, Zhi, Pei Zhi Cheryl, Chia, Cheryl, Chia, Paul A, Gleeson   +3 more
openaire   +2 more sources

Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo [PDF]

, 2016
BACKGROUND: The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark pathology of Alzheimer’s disease (AD). Previous work has shown increasing serotonin levels with selective serotonin re-uptake inhibitor (SSRI) compounds reduces Aβ in the ...
Cirrito, John R, Fisher, Jonathan R, Sheline, Yvette I, Tripoli, Danielle L, Wallace, Clare E   +4 more
core   +2 more sources

Alphafuser: a parsimonious approach to predicting higher‐order protein complexes

Acta Crystallographica Section D, Volume 82, Issue 5, Page 421-433, May 2026.
Alphafuser is a structure‐prediction pipeline that integrates experimental interaction data with AlphaFold‐based modeling to systematically assemble multiprotein complexes in a computationally efficient manner. By implementing an ipTM‐based pruning algorithm and validating against known structures and experimental assays, Alphafuser enables the ...
Audrey Guillotin, Stephanie Hutin, Lorelei Masselot-Joubert, Kamel Hammani, Chloe Zubieta, Max Nanao   +5 more
wiley   +1 more source

Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage

Neuropharmacology, 2014
Amyloid precursor protein (APP) shedding yields the Alzheimer's disease (AD)-related peptide amyloid β (Aβ) through β- and γ-secretase cleavage. Alternatively, α-secretase cleavage generates a soluble and neuroprotective fragment (sAPPα) while precludes the production of Aβ.
Durand, Daniela Elizabeth, Carniglia, Lila, Beauquis, Juan, Caruso, Carla Mariana, Saravia, Flavia Eugenia, Lasaga, Mercedes Isabel   +5 more
openaire   +3 more sources

Secreted APP Regulates the Function of Full-Length APP in Neurite Outgrowth Through Interaction With Integrin Beta1 [PDF]

, 2011
Background: β-Amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons. Both cell-surface APP and its soluble, ectodomain cleavage product (APPs-α) have been implicated in regulating the length ...
Chang, Rui, Chen, Allen Ching-Way, Marquez, Cesar, Selkoe, Dennis J., Young-Pearse, Tracy L   +4 more
core   +1 more source

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Sean J. Miller, Dmitry Prokopenko, Ping Bai, Prasenjit Mondal, Abigael Scott, Wei Zhang, Ashley Gomm, Siyi Zhang, Daniel D. Child, Nolan Shen, Joseph Ward, Scott Schulte, Dan Lei, Brian P. Hafler, Changning Wang, Rudolph E. Tanzi, Can Zhang   +16 more
wiley   +1 more source