Results 91 to 100 of about 14,107 (263)

Shedding of APP limits its synaptogenic activity and cell adhesion properties

Frontiers in Cellular Neuroscience, 2014
The Amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its ...
Ronny eStahl, Ronny eStahl, Sandra eSchilling, Peter eSoba, Carsten eRupp, Tobias eHartmann, Katja eWagner, Gunter eMerdes, Simone eEggert, Stefan eKins   +9 more
doaj   +1 more source

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains

Molecular Brain, 2021
Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits has been directly linked to altered generation
Shekhar Kedia, Kousik Mandal, Pallavi Rao Netrakanti, Mini Jose, Sangram S. Sisodia, Deepak Nair   +5 more
doaj   +1 more source

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH [PDF]

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen, Chibuu Liu, Christina Sidera   +2 more
core   +2 more sources

Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's Disease (AD) is a central nervous system (CNS) neurodegenerative disease leading to dementia, but can also show symptoms of motor deficits. It is not clear whether the peripheral motor deficits in AD are derived from upstream centers or intrinsic to the neuromuscular circuit.
Akhmetzada Kargazhanov, Romy Aiken, Kenneth Hawkins, Rafael Lopez, Ahmad Nawaz, Gaurav Srivastava, Chase Miller, Will Bogen, Christopher Long, David Morgan, Xiufang Guo, James Hickman   +11 more
wiley   +1 more source

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

Neurobiology of Disease, 2005
In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux, Malika Hamdane, Marie Gompel, Séverine Bégard, Hervé Drobecq, Antoine Ghestem, Marie-Eve Grosjean, Vesna Kostanjevecki, Pierre Grognet, Eugeen Vanmechelen, Luc Buée, André Delacourte, Nicolas Sergeant   +12 more
doaj   +1 more source

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION While the apolipoprotein E (APOE) ε4 allele is a major risk factor for Alzheimer's disease (AD), the role of translocase of outer mitochondrial membrane 40 (TOMM40)—an adjacent gene involved in mitochondrial protein import—is not known. METHODS Human brain tissue, human induced pluripotent stem cell–derived neurons (iNeurons), and
Neil V. Yang, Shaowei Wang, Boyang Li, Jeffrey Simms, Linsey Dinh, Annie Huang, Jacob H. Oei, Hussein N. Yassine, Ronald M. Krauss   +8 more
wiley   +1 more source

Endosomal Sorting of Amyloid Precursor Protein‐P‐Selectin Chimeras Influences Secretase Processing [PDF]

Traffic, 2001
Amyloid β protein, the major component of the senile plaques in Alzheimer's disease, is generated by secretory and endocytic processing of amyloid precursor protein. Internalized amyloid precursor protein either recycles to the plasma membrane, where α‐secretase resides, or moves to acidic compartment(s) for β‐secretase exposure.
B L, Daugherty, S A, Green
openaire   +2 more sources

The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2018
The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s ...
Hongfeng Zhang, Timothy Huang, Yujuan Hong, Weijie Yang, Xian Zhang, Hong Luo, Huaxi Xu, Huaxi Xu, Xin Wang   +8 more
doaj   +1 more source

Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder

Frontiers in Psychiatry, 2019
The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged.
Deborah K. Sokol, Bryan Maloney, Cara J. Westmark, Debomoy K. Lahiri, Debomoy K. Lahiri   +4 more
doaj   +1 more source

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein [PDF]

, 2016
Despite existing knowledge about the role of the A Disintegrin and Metalloproteinase 10 (ADAM10) as the α-secretase involved in the non-amyloidogenic processing of the amyloid precursor protein (APP) and Notch signalling we have only limited information ...
Altmeppen, Hermann, Boland, Barry, Damme, Markus, Glatzel, Markus, Kasparek, Petr, Prox, Johannes, Rabe, Bjorn, Saftig, Paul, Sedlacek, Radislav, Seipold, Lisa, Willem, Michael   +10 more
core   +1 more source