Results 111 to 120 of about 99,289 (260)

Beyond the Heart: Hepatic Extracellular Volume Assessment in Patients With Cardiovascular Disease

Journal of Magnetic Resonance Imaging, EarlyView.
Kenichiro Suwa, Yuichiro Maekawa
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Attrition rates and treatment outcomes in multiple myeloma: real-world data over a 40-year period

Blood Cancer Journal
The treatment landscape of multiple myeloma (MM) has evolved significantly over four decades, driven by novel therapies and optimized supportive care. However, the attrition rate (AR), defined as the proportion of patients who die without advancing to ...
Luis Gerardo Rodríguez-Lobato, Anna de Daniel, Arturo Pereira, Carlos Fernández de Larrea, Natalia Tovar, M. Teresa Cibeira, David F. Moreno, Jose Miguel Mateos, Noemí Llobet, Esther Carcelero, Daniel Munárriz, Joan Bladé, Laura Rosiñol   +12 more
doaj   +1 more source

Light Chain Monoclonal Gammopathy of Undetermined Significance: Diagnosis, Biology, and Clinical Management

European Journal of Haematology, EarlyView.
ABSTRACT Light chain monoclonal gammopathy of undetermined significance (LC‐MGUS) is defined by an abnormal serum free light chain ratio and elevated involved light chain in the absence of a detectable immunoglobulin heavy chain on immunofixation and of end‐organ damage attributable to a plasma cell disorder.
Sigurður Yngvi Kristinsson, Thórir Einarsson Long, Sigrún Thorsteinsdóttir   +2 more
wiley   +1 more source

Gradually Enlarging Nodular Pulmonary Amyloidosis Associated With Sjögren's Syndrome. [PDF]

Respirol Case Rep
A woman with Sjögren's syndrome presented with progressively enlarging pulmonary nodules showing calcification and cystic changes, mimicking metastatic malignancy. Histological examination confirmed AL λ‐type nodular pulmonary amyloidosis. Recognition of this radiological pattern is important to avoid misdiagnosis and unnecessary invasive interventions.
Morikawa N, Mikami S, Suzuki D.
europepmc   +2 more sources

Prevalence and Disability of Peripheral Neuropathy in Patients With Waldenström's Macroglobulinemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Peripheral neuropathy (PN) is considered a frequent complication of Waldenström's macroglobulinemia (WM). Establishing a causal relationship between PN and WM is complicated by confounding factors such as age‐related axonal loss and diabetes. This scoping review aims to summarize the current evidence on WM‐associated PN with a focus
Morten Müller Aagaard, Kristoffer Nagy Skaastrup, Louise Sloth Kodal, Britt Stævnsbo Pedersen, Troels Hammer, John Vissing, Tina Dysgaard   +6 more
wiley   +1 more source

Early‐Onset Wild‐Type Transthyretin Amyloidosis Polyneuropathy

Muscle &Nerve, EarlyView.
Chafic Karam, Kaylee Baker, Sami Khella, Brian Drachman, Pranav Chandrashekar, MacLean Nasrallah, Shunsuke Koga, Janice Pieretti   +7 more
wiley   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Stringent patient selection improves outcomes in systemic light-chain amyloidosis after autologous stem cell transplantation in the upfront and relapsed setting

Haematologica, 2014
Christopher P. Venner, Julian D. Gillmore, Sajitha Sachchithanantham, Shameem Mahmood, Thirusha Lane, Darren Foard, Murielle Roussel, Lisa Rannigan, Simon DJ Gibbs, Jennifer H Pinney, Carol J. Whelan, Helen J. Lachmann, Philip N. Hawkins, Ashutosh D. Wechalekar   +13 more
doaj   +1 more source

Neurological affection and serum neurofilament light chain in wild type transthyretin amyloidosis

Scientific Reports
In contrast to inherited transthyretin amyloidosis (A-ATTRv), neuropathy is not a classic leading symptom of wild type transthyretin amyloidosis (A-ATTRwt). However, neurological symptoms are increasingly relevant in A-ATTRwt as well.
Helena F. Pernice, Adrian L. Knorz, Paul J. Wetzel, Carolin Herrmann, Harisa Muratovic, Finn Rieber, Eleonora Asaad, Gunnar Fiß, Gina Barzen, Elisabeth Blüthner, Fabian Knebel, Sebastian Spethmann, Daniel Messroghli, Bettina Heidecker, Anna Brand, Christoph Wetz, Carsten Tschöpe, Katrin Hahn   +17 more
doaj   +1 more source