Results 111 to 120 of about 90,332 (308)

Ethnicity in systemic AL amyloidosis may impact risk stratification

Haematologica
Not available.
Jahanzaib Khwaja, Sriram Ravichandran, Oliver Cohen, Darren Foard, Ana Martinez – Naharro, Lucia Venneri, Carol Whelan, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Shameem Mahmood, Marianna Fontana, Ashutosh Wechalekar   +12 more
doaj   +1 more source

Guidance for the assessment of the dietary intake and gastrointestinal or nutrition impact symptoms etiologic criterion of Global Leadership Initiative on Malnutrition: A modified‐Delphi study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The GLIM malnutrition diagnostic framework includes the etiologic criterion for reduced dietary intake or assimilation (i.e., digestion or absorption). This criterion required further specification to support consistent use in clinical practice.
Renée Blaauw, Heather Keller, Christine Marie Mills, Gert Bischoff, Charlene Compher, Marian de van der Schueren, Krista Haines, Nicole Kiss, Charles Lew, Ainsley Malone, Claudia Maza Moscoso, Nancy Stoner, Rocco Barazzoni, Jack J. Bell, Madeleine Coetzee, M. Isabel T. D. Correia, Ryoji Fukushima, Elena George, M. Cristina Gonzalez, Leah Gramlich, Yen Peng Lim, Roseann Nasser, Matthias Pirlich, Jacqueline A. E. Langius, Terese Scollard, Nicolette Wierdsma, Marion Winkler, Tommy Cederholm, Gordon L. Jensen   +28 more
wiley   +1 more source

Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis

Pharmaceuticals
Background/Objectives: Antibody light chains form amyloid fibrils that lead to progressive tissue damage in amyloid light chain (AL) amyloidosis. The properties of each patient’s unique light chain appear to determine its propensity to form amyloid.
Gareth J. Morgan, Zach Yung, Brian H. Spencer, Vaishali Sanchorawala, Tatiana Prokaeva   +4 more
doaj   +1 more source

A Refractory Leg Skin Ulcer Associated With Multiple Myeloma Successfully Treated With Plasma Exchange, Lenalidomide, and Dexamethasone

JEADV Clinical Practice, EarlyView.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori, Yutaka Kuwatsuka, Tomoka Waseda, Daisuke Ehara, Koji Ando, Hiroyuki Murota   +5 more
wiley   +1 more source

Successful Treatment of Refractory Lichen Amyloidosus With Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Lichen amyloidosis (LA) is a chronic, pruritic dermatosis with papillary dermal amyloid deposition. Standard therapies often fail, and most reports of dupilumab in LA involve patients with concomitant atopic dermatitis. We report a 32‐year‐old man with refractory, non‐atopic LA who had failed topical corticosteroids, tacrolimus, phototherapy ...
Sohrab Elahwiesy, Franziska Jochims, Manfred Kunz, Susann Forkel, Jan‐Christoph Simon, Benjamin Klein   +5 more
wiley   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Attrition rates and treatment outcomes in multiple myeloma: real-world data over a 40-year period

Blood Cancer Journal
The treatment landscape of multiple myeloma (MM) has evolved significantly over four decades, driven by novel therapies and optimized supportive care. However, the attrition rate (AR), defined as the proportion of patients who die without advancing to ...
Luis Gerardo Rodríguez-Lobato, Anna de Daniel, Arturo Pereira, Carlos Fernández de Larrea, Natalia Tovar, M. Teresa Cibeira, David F. Moreno, Jose Miguel Mateos, Noemí Llobet, Esther Carcelero, Daniel Munárriz, Joan Bladé, Laura Rosiñol   +12 more
doaj   +1 more source

Light-chain cardiac amyloidosis with neuropathy: a case report

, 2015
Zhan-Wen Xu,1 Ya-Qin Li,1 Li-xia Liu,2 Bing-Juan Zhou3 1Department of Cardiology, 2Department of Ultrasound, Affiliated Hospital of Hebei University, 3Department of Pathology, Baoding First Central Hospital, Baoding, People’s Republic of China ...
Li YQ, Liu LX, Xu ZW, Zhou BJ
core  

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Analysis of Distal Compound Muscle Action Potential Duration in Hereditary Transthyretin Amyloidosis with Polyneuropathy [PDF]

Background : Hereditary transthyretin (ATTRv) amyloidosis, a disorder accompanied by axonal polyneuropathy, is often misdiagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP).
Hoshino, Yumi, Kodaira, Minori, Ohashi, Nobuhiko, Sekijima, Yoshiki, Morita, Hiroshi   +4 more
core   +1 more source