Results 131 to 140 of about 31,379 (232)

Neurological affection and serum neurofilament light chain in wild type transthyretin amyloidosis

Scientific Reports
In contrast to inherited transthyretin amyloidosis (A-ATTRv), neuropathy is not a classic leading symptom of wild type transthyretin amyloidosis (A-ATTRwt). However, neurological symptoms are increasingly relevant in A-ATTRwt as well.
Helena F. Pernice, Adrian L. Knorz, Paul J. Wetzel, Carolin Herrmann, Harisa Muratovic, Finn Rieber, Eleonora Asaad, Gunnar Fiß, Gina Barzen, Elisabeth Blüthner, Fabian Knebel, Sebastian Spethmann, Daniel Messroghli, Bettina Heidecker, Anna Brand, Christoph Wetz, Carsten Tschöpe, Katrin Hahn   +17 more
doaj   +1 more source

Cardiac Amyloidosis

Heart Views, 2021
Salah Elbdri, Rachel Hajar
openaire   +3 more sources

Amyloidosis in Heart Failure

, 2019
Purpose: Amyloidosis represents an increasingly recognized but still frequently missed cause of heart failure. In the light of many effective therapies for light chain (AL) amyloidosis and promising new treatment options for transthyretin (ATTR ...
Stork S., Morbach C., Palladini G., Obici L., Ihne S.   +4 more
core   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Stringent patient selection improves outcomes in systemic light-chain amyloidosis after autologous stem cell transplantation in the upfront and relapsed setting

Haematologica, 2014
Christopher P. Venner, Julian D. Gillmore, Sajitha Sachchithanantham, Shameem Mahmood, Thirusha Lane, Darren Foard, Murielle Roussel, Lisa Rannigan, Simon DJ Gibbs, Jennifer H Pinney, Carol J. Whelan, Helen J. Lachmann, Philip N. Hawkins, Ashutosh D. Wechalekar   +13 more
doaj   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Comparison of the HemoScreen Point‐Of‐Care Haematology Analyser With Sysmex XN, Beckman Coulter DxH 560 and HORIBA Yumizen H550 in Patients With Abnormal Blood Counts

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction HemoScreen is a portable point‐of‐care testing (POCT) haematology analyser capable of measuring 20 complete blood count (CBC) parameters, including a 5‐part leukocyte differential, from venous and capillary blood. This study compared selected CBC and white blood cell (WBC) differential parameters obtained using HemoScreen with ...
Katarína Hradská, Martin Pulcer, Michaela Skořupová, Tereza Popková, Michal Kaščák, Jana Mihályová, Ivo Demel, Barbora Dluhošová, Kateřina Benková, Juraj Ďuraš, Soňa Kolářová, Veronika Hanzelková, Simona Pulcerová, Roman Hájek   +13 more
wiley   +1 more source

Primary localized conjunctival amyloidosis: A case report with a ten-year follow-up period

, 2008
Juan Carlos Mesa-Gutiérrez, Tomás Martí Huguet, Noemí Barnils Garcia, Jorge Arruga GinebredaDepartment of Ophthalmology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona ...
Jorge Arruga Ginebreda, Noemí Barnils Garcia, Juan Carlos Mesa-Gutiérrez, Tomás Martí Huguet   +3 more
core  

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source

Amyloidosis: a clinical overview.

Rheumatic diseases clinics of North America, 2013
Amyloidosis is the name for protein-folding diseases characterized by extracellular deposition of a specific soluble precursor protein that aggregates in the form of insoluble fibrils. The classification of amyloidosis is based on the chemical characterization of the precursor protein. Deposition of amyloid is localized or systemic. The 4 main types of
openaire   +2 more sources