Results 21 to 30 of about 242,580 (385)

Amyotrophic lateral sclerosis: a clinical review

European Journal of Neurology, 2020
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting primarily the motor system, but in which extra‐motor manifestations are increasingly recognized.
Pegah Masrori, P. van Damme
semanticscholar   +1 more source

Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis [PDF]

, 2020
The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected ...
Burke, David, deCarvalho, Mamede, Grosskreutz, Julian, Kiernan, Matthew C, Leigh, P Nigel, Swash, Michael, Turner, Martin R   +6 more
core   +1 more source

Amyotrophic lateral sclerosis viewed from a patient’s perspective

Monaldi Archives for Chest Disease, 2016
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M. Melazzini
doaj   +1 more source

Different observation period of exercise training in amyotrophic lateral sclerosis patients: A meta-analysis

Frontiers in Neurology, 2022
ObjectiveThe purpose of this meta-analysis was to evaluate the effect of more intensive exercise training on the functional ability of patients with amyotrophic lateral sclerosis.MethodsRandomized controlled trials on exercise training in amyotrophic ...
Baohua Zhou, Jiajun Wei, Yanli Zhang, Yue Liu, Shuhui Shan, Shan Ye, Baohua Li, Dongsheng Fan, Yongmei Luo   +8 more
doaj   +1 more source

Eye Tracking Impact on Quality-of-Life of ALS Patients [PDF]

, 2008
Chronic neurological disorders in their advanced phase are characterized by a progressive loss of mobility (use of upper and lower limbs), speech and social life.
And Vignola, A., Calvo, A., Castellina, Emiliano, Chiò, A., Corno, Fulvio, Farinetti, Laura, Ghiglione, P., Pasian, V.   +7 more
core   +1 more source

Amyotrophic Lateral Sclerosis

, 2020
Chapter to be included in the volume Pragmatic Language Disorders: Complex and Underserved Populations, Ed. Louise Cummings, Springer, 2020. It reviews findings that have contributed to our understanding of pragmatic impairment in ALS.
Ceroni, Mauro, Bambini , Valentina
openaire   +3 more sources

Control in the absence of choice: A qualitative study on decision-making about gastrostomy in people with amyotrophic lateral sclerosis, caregivers, and healthcare professionals.

PLoS ONE, 2023
BackgroundGastrostomy is recommended in amyotrophic lateral sclerosis for long-term nutritional support, however, people with amyotrophic lateral sclerosis and healthcare professionals perceive decision-making as complex.MethodTo explore their ...
Remko M van Eenennaam, Neele Rave, Willeke J Kruithof, Esther T Kruitwagen-van Reenen, Leonard H van den Berg, Johanna A Visser-Meily, Anita Beelen   +6 more
doaj   +1 more source

Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord

Brain : a journal of neurology, 2022
Aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (SOD1) has been widely examined in silico, in vitro and in transgenic animal models of amyotrophic lateral sclerosis.
B. G. Trist, Sian Genoud, Stéphane Roudeau, Alexander Rookyard, Amr H. Abdeen, Veronica Cottam, D. Hare, Melanie Y. White, Jens Altvater, J. Fifita, A. Hogan, N. Grima, I. Blair, K. Kysenius, P. Crouch, A. Carmona, Yann Rufin, S. Claverol, Stijn J. M. Van Malderen, G. Falkenberg, D. Paterson, Bradley N. Smith, C. Troakes, C. Vance, C. Shaw, S. Al-Sarraj, S. Cordwell, G. Halliday, R. Ortega, K. Double   +29 more
semanticscholar   +1 more source

Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis [PDF]

, 2010
The finding of TDP-43 as a major component of ubiquitinated protein inclusions in amyotrophic lateral sclerosis (ALS) has led to the identification of 30 mutations in the transactive response-DNA binding protein (TARDBP) gene, encoding TDP-43.
A Yokoseki, BA Hosler, C Lomen-Hoerth, C Vance, Christopher J. McDermott, D Neary, DR Rosen, E Buratti, E Buratti, E Kabashi, Emily F. Goodall, F Gros-Louis, GM Ringholz, H Daoud, Hannah C. Hollinger, I Gijselinck, IF Wang, IR Mackenzie, J Kirby, J Sreedharan, J. Robin Highley, Janine Kirby, JJ Kew, Judith A. Hartley, Karen E. Morrison, L Benajiba, L Corrado, M Morita, M Neumann, MJ Strong, MJ Winton, NJ Rutherford, P Kuhnlein, PA Mercado, Pamela J. Shaw, Paul G. Ince, PM Andersen, R Bo Del, R Lemmens, Rachel Hibberd, RJ Guerreiro, Rudo Masanzu, SH Ou, Stephen B. Wharton, VM Deerlin Van, William Smith, YM Ayala   +46 more
core   +1 more source

Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches

BMC Neurology, 2017
Background Adult neurogenesis persists through life at least in classic neurogenic niches. Neurogenesis has been previously described as reduced in neurodegenerative diseases.
Lucía Galán, Ulises Gómez-Pinedo, Antonio Guerrero, Jose Manuel García-Verdugo, Jorge Matías-Guiu   +4 more
doaj   +1 more source