Results 201 to 210 of about 42,863 (306)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

open access: yesVIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li   +5 more
wiley   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu   +7 more
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

open access: yesIntegrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang   +6 more
wiley   +1 more source

The Effects of Noise on the Juvenile Life Stage of Crustaceans: Behavioral, Cellular, and Molecular Responses in Procambarus clarkii

open access: yesIntegrative Zoology, EarlyView.
Juvenile Procambarus clarkii exposed to noise exhibited behavioral changes, shifts in enzymatic activity, and altered expression of stress and immune genes. The findings highlight the sensitivity of invertebrate juveniles to anthropogenic acoustic pollution.
Maria Ceraulo   +8 more
wiley   +1 more source

NsPEFs-enriched ADSCs-EVs alleviate osteoarthritis via RSPO3-mediated dual pro-chondrogenic and pro-M2 macrophage properties. [PDF]

open access: yesBioact Mater
Wang Y   +15 more
europepmc   +1 more source

What anabolic–androgenic steroids reveal about the limits of current harm reduction models

open access: yesAddiction, EarlyView.
Abstract Background Harm reduction has largely been shaped by responses to psychoactive drug use where the most urgent harms are acute. These models focus on overdose, blood‐borne viruses, and rapid‐onset toxicity related harms. When applied wholesale to anabolic–androgenic steroids (AAS), they obscure the distinctive pharmacology, consumer typologies,
Timothy Piatkowski   +2 more
wiley   +1 more source

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