Results 51 to 60 of about 24,072 (312)

Mitigating disuse‐induced skeletal muscle atrophy in ageing: Resistance exercise as a critical countermeasure

Experimental Physiology
The gradual deterioration of physiological systems with ageing makes it difficult to maintain skeletal muscle mass (sarcopenia), at least partly due to the presence of ‘anabolic resistance’, resulting in muscle loss.
James McKendry, Giulia Coletta, Everson A. Nunes, Changhyun Lim, Stuart M. Phillips   +4 more
doaj   +1 more source

Androgenic Steroid Hormones and Endurance Exercise in Athletic Women

Endocrines
This study investigated the impact of intensive endurance exercise on circulating androgenic steroid hormones in women. Fifteen normally menstruating athletic women participated.
Anthony C. Hackney, Raul Cosme Ramos Prado, Eimear Dolan   +2 more
doaj   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

IL-1ß and BMPs - Interactive players of cartilage matrix degradation and regeneration [PDF]

European Cells & Materials, 2006
Intact human adult articular cartilage is central for the functioning of the articulating joints. This largely depends on the integrity of its extracellular matrix, given the high loading forces during movements in particular in the weight-bearing joints.
T Aigner, S Soeder, J Haag
doaj  

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Influencia de la infección por VIH/sida sobre algunos indicadores bioquímicos del estado nutricional

Biomédica: revista del Instituto Nacional de Salud, 2002
Con el objetivo de analizar la influencia de la infección por el VIH y el estadio clínico de la enfermedad sobre indicadores bioquímicos del estado nutricional del individuo, se estudió un grupo de individuos infectados y clasificados en diferentes ...
Maritza E. Linares, J. F. Bencomo, L. E. Pérez, O. Barrera   +3 more
doaj   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Effects of training on bone metabolism in young athletes

Human Movement, 2021
Antti M.J. Mero, Keijo Häkkinen, Heikki Kyröläinen, Antti A. Mero   +3 more
doaj   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source