Results 61 to 70 of about 42,863 (306)

Ischemic nucleotide breakdown increases during cardiac development due to drop in adenosine anabolism/catabolism ratio [PDF]

, 1990
Our earlier work on reperfusion showed that adult rat hearts released almost twice as much purine nucleosides and oxypurines as newborn hearts did [Am J Physiol 254 (1988) H1091].
Huizer, T. (Tom), Jong, J.W. (Jan Willem) de, Keijzer, E. (Elisabeth), Schoutsen, B.   +3 more
core   +2 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Conceptual Understanding of Brimhana karma

Journal of Ayurveda
Objective:In the present-day world, the emergence of various debilitating diseases as well as medical treatments is rendering people to be weak and emaciated, hence pointing at the necessity to understand Brimhana karma of Ayurveda which may be equated ...
Manjula, Sudipt Rath, Mita Kotecha
doaj   +1 more source

Intervertebral disc response to stem cell treatment is conditioned by disc state and cell carrier: An ex vivo study

Journal of Orthopaedic Translation, 2017
In vitro and in vivo studies evidenced that mesenchymal stem cells (MSCs) contribute to intervertebral disc (IVD) regeneration by differentiation towards the disc phenotype and matrix synthesis and/or by paracrine signalling to endogenous cells, thereby ...
Marianna Peroglio, Luzia Simone Douma, Tansinee Stephanie Caprez, Milena Janki, Lorin Michael Benneker, Mauro Alini, Sibylle Grad   +6 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Regulation of Dietary Lipid Sources on Tissue Lipid Classes and Mitochondrial Energy Metabolism of Juvenile Swimming Crab, Portunus trituberculatus

Frontiers in Physiology, 2019
An 8-weeks feeding trial with swimming crab, Portunus trituberculatus, was conducted to investigate the effects of different dietary lipid sources on the lipid classes, lipid metabolism, and mitochondrial energy metabolism relevant genes expression.
Ye Yuan, Peng Sun, Min Jin, Xuexi Wang, Qicun Zhou   +4 more
doaj   +1 more source

Maximizing efficiency of rumen microbial protein production. [PDF]

, 2015
Rumen microbes produce cellular protein inefficiently partly because they do not direct all ATP toward growth. They direct some ATP toward maintenance functions, as long-recognized, but they also direct ATP toward reserve carbohydrate synthesis and ...
Andries, Argyle, Armstead, Asanuma, Asanuma, Atasoglu, Atasoglu, Atasoglu, Bailey, Bailey, Baldwin, Baldwin, Bas, Bond, Bond, Bond, Buurman, Caldara, Chen, Cheng, Clapperton, Clark, Cook, Costerton, Cotta, Cotta, Counotte, Denton, Diaz, Diez-Gonzalez, Dijkstra, Dijkstra, Dijkstra, Duncan, Dunne, Falony, Ferla, Fields, Firkins, Firkins, Firkins, Firkins, Flint, Forsberg, Gaudet, Gottschalk, Hackmann, Hackmann, Hackmann, Hall, Hanigan, Hindson, Hino, Hobson, Hobson, Hottiger, Hristov, Hristov, Isaacson, Janssen, Jenkins, Jouany, Kajikawa, Kajikawa, Kajikawa, Kalcheva, Karnati, Kim, Koenig, Krause, Kristensen, Larsson, Leedle, Lohkamp, Lou, Lou, Lou, Louis, Mackie, Maia, Martin, Matheron, Matulova, McAllan, Morgan, Morgavi, Morrison, Morrison, Mountfort, Mouriño, Mulder, Nagaraja, Neijssel, Newbold, Newsholme, Newsholme, Nouaille, NRC., Oldick, Or-Rashid, Otto, Paillard, Paulus, Pirt, Piwonka, Portais, Prabhu, Preiss, Prins, Rosewarne, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Ryan, Saleem, Schönheit, Shi, Shi, Stewart, Storm, Stouthamer, Suen, Teixeira de Mattos, Tempest, Tempest, Ungerfeld, van Hijum, Van Hoven, Van Kessel, Van Kessel, Van Soest, Van Urk, Vandehaar, Walker, Wallace, Wallace, Wang, Weimer, Weimer, Weimer, Wells, Wells, White, Wilkinson, Williams, Williams, Yang, Ze, Zhou   +158 more
core   +2 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

LOXL2 in anabolic response to chondrodysplasia mice progressive TMJ and knee osteoarthritis [PDF]

, 2019
Osteoarthritis (OA) is a degenerative joint disease that affects an estimated 9.6 % of men and 18 % of women over 60 years of age. However, there is no chondroprotective agent that is approved for clinical application.
Alsaqer, Saqer
core  

Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity [PDF]

, 2016
BackgroundAgeing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss. We investigated whether anabolic resistance to feeding might underlie accelerated muscle loss in older people with T2DM and whether dysregulated mTOR ...
Babraj, John, Cuthbertson, Daniel J., Leese, Graham, Siervo, Mario   +3 more
core   +4 more sources