Results 81 to 90 of about 42,863 (306)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Effects of training on bone metabolism in young athletes

Human Movement, 2021
Antti M.J. Mero, Keijo Häkkinen, Heikki Kyröläinen, Antti A. Mero   +3 more
doaj   +1 more source

Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer [PDF]

, 2019
PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass.
Deutz, Nicolaas Ep, Engelen, Marielle Pkj, Teleni, Laisa, van der Meij, Barbara S   +3 more
core   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition [PDF]

, 2015
Although the prevalence of malnutrition in the old age is increasing worldwide a synthetic understanding of the impact of aging on the intake, digestion, and absorption of nutrients is still lacking.
Bordoni, Alessandra, Dupont, Didier, Gille, Doreen, Kachal, Josefa, Peyron, Marie-Agnès, Pinto, Paula, Rémond, Didier., Santos, Claudia Nunes Dos, Shahar, Danit R., Tomás-Cobos, Lidia, Vergères, Guy, Walther, Barbara   +11 more
core   +4 more sources

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science
Cell proliferation requires anabolic supports. How the cell cycle integrates anabolism remains poorly understood. Herein, it is identified that G1‐phase regulator cell division cycle 20‐like protein 1 (CDH1) coordinates anabolic events to ensure cell ...
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
doaj   +1 more source

Influencia de la infección por VIH/sida sobre algunos indicadores bioquímicos del estado nutricional

Biomédica: revista del Instituto Nacional de Salud, 2002
Con el objetivo de analizar la influencia de la infección por el VIH y el estadio clínico de la enfermedad sobre indicadores bioquímicos del estado nutricional del individuo, se estudió un grupo de individuos infectados y clasificados en diferentes ...
Maritza E. Linares, J. F. Bencomo, L. E. Pérez, O. Barrera   +3 more
doaj   +1 more source

Effects of Δtor1 on Yeast Longevity via Chronological Lifespan Assay [PDF]

, 2017
TOR1 is known to extend chronological lifespan in S. cerevisiae. Δtor1 deletion was studied via chronological lifespan assay and environmental oxidative stress test.
Bestwick, Megan, Keyes, Amelia
core   +1 more source

Nutrient availability affects carbon turnover and microbial physiology differently in topsoil and subsoil under a temperate grassland [PDF]

, 2018
Increasing subsoil organic carbon inputs could potentially mitigate climate change by sequestering atmospheric CO2. Yet, microbial turnover and stabilization of labile carbon in subsoils are regulated by complex mechanisms including the availability of ...
Elsgaard, Lars, Jensen, Johannes L., Liang, Zhi, Olesen, Jørgen E.   +3 more
core   +1 more source