Results 91 to 100 of about 27,543 (304)

Quantification and interpretation of postprandial whole-body protein metabolism using stable isotope methodology: a narrative review

Frontiers in Nutrition
Stable isotopes are routinely applied to determine the impact of factors such as aging, disease, exercise, and feeding on whole-body protein metabolism.
Jorn Trommelen, Luc J. C. van Loon
doaj   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Effects of dietary APP on gene expression of the regulators involved in catabolism, anabolism, and myogenic process in immobilized limbs after recovery period.

, 2019
Effects of dietary APP on gene expression of the regulators involved in catabolism, anabolism, and myogenic process in immobilized limbs after recovery period.
Takafumi Mizushige (6843308), Keisuke Uozumi (6843314), Bhattarai Keshab (6843323), Taro Kishida (1385013), Machi Yasui (6843317), Kohsuke Hayamizu (6843320), Shinji Okada (190564), Kenji Uchida (2520589), Mina Fujitani (6843305), Fuminori Kawabata (6843311)   +9 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals

Frontiers in Nutrition
Essential amino acid (EAA)-based compositions have been shown to be effective stimulators of muscle protein synthesis, but the lower limit of effective dosage is not clear. We have used stable isotope tracer methodology to quantify the response of muscle
David D. Church, Arny A. Ferrando, Robert R. Wolfe   +2 more
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Regulation of muscle protein metabolism by nutrition and exercise

Journal of Physical Fitness and Sports Medicine, 2017
Skeletal muscle is an essential tissue that regulates glucose metabolism and locomotive ability. Therefore, gaining skeletal muscle mass is important for maintaining or improving health as well as athletic sport performance.
Satoru Ato, Satoshi Fujita
doaj   +1 more source

Turnover of pigment granules: Cyclic catabolism and anabolism of ommochromes within epidermal cells

, 2009
International audienceOmmochromes are end products of the tryptophan metabolism in arthropods. While the anabolism of ommochromes has beenwell studied, the catabolism is totally unknown.
Insausti, Teresita, C., Casas, Jérome
core   +1 more source

Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia [PDF]

, 2012
Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested.
Papet, Isabelle, Papet, Isabelle, I., Isabelle Papet, Marie-Agnès Peyron, Laurent Mosoni, Mosoni, Laurent, Peyron, Marie-Agnès, Auzeloux, Isabelle, Dominique Dardevet, Didier Rémond, Dardevet, Dominique, Remond, Didier, Savary-Auzeloux, Isabelle, Isabelle Savary-Auzeloux   +13 more
core   +1 more source