Results 91 to 100 of about 42,863 (306)

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Effects of ingesting protein with various forms of carbohydrate following resistance-exercise on substrate availability and markers of anabolism, catabolism, and immunity [PDF]

, 2007
Background Ingestion of carbohydrate (CHO) and protein (PRO) following intense exercise has been reported to increase insulin levels, optimize glycogen resynthesis, enhance PRO synthesis, and lessen the immuno-suppressive effects of intense exercise ...
Richard B Kreider, Conrad P Earnest, Jennifer Lundberg, Christopher Rasmussen, Michael Greenwood, Patricia Cowan, Anthony L Almada   +6 more
core   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes [PDF]

, 2013
The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear.
Allen, Matthew R., Bellido, Teresita, Condon, Keith W., Lee, Eun-Young, Lezcano, Virginia, Plotkin, Lilian I., Rhee, Yumie, Ronda, Ana C.   +7 more
core   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Sports foods and dietary supplements for optimal function and performance enhancement in track and field athletes [PDF]

, 2009
Numerous nutritional products are marketed with claims of optimizing athlete health and function and/or enhancing performance. Products that fall under the banner of “Sports Foods” or “Dietary Supplements,” may be used to support performance during ...
Peeling, Peter, Castell, Linda M., Derave, Wim, de Hon, Olivier, Burke, Louise M.   +4 more
core   +1 more source

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats [PDF]

, 2013
Prolonged inactivity induces muscle loss due to an activation of proteolysis and decreased protein synthesis; the latter is also involved in the recovery of muscle mass.
Auzeloux, Isabelle, Breuillé, Denis, Combaret, Lydie, Dardevet, Dominique, Faure, Magali, Magne, Hugues, Migné, Carole, Oberli, Marion, Perrot, Marie, Remond, Didier, Vidal, Karine   +10 more
core   +4 more sources

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

The Biosphere as a Living System. On Peculiarities of the Evolutionary Process on the Biosphere Level [PDF]

Философия и космология, 2016
The main purpose of this second essay the “biospherology” is to streamline and formalize the existing knowledge about the biosphere, to develop the theoretical basis of the theory of evolution of the biosphere. Despite the vast amount of research on ways
Alexej Yablokov, Vladimir Levchenko, Anatolij Kerzhentsev   +2 more
doaj  

Regulation of muscle protein metabolism by nutrition and exercise

Journal of Physical Fitness and Sports Medicine, 2017
Skeletal muscle is an essential tissue that regulates glucose metabolism and locomotive ability. Therefore, gaining skeletal muscle mass is important for maintaining or improving health as well as athletic sport performance.
Satoru Ato, Satoshi Fujita
doaj   +1 more source