Results 71 to 80 of about 29,332 (238)

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Autophagy is Required for mTOR-Mediated Anabolism in Skeletal Muscle [PDF]

, 2023
PURPOSE: While much has been discovered about the role autophagy in protein degradation, recent evidence suggests that autophagy is required for muscular adaptations to exercise, hinting at a hitherto unknown cross-talk between autophagic proteolysis and
Cardin, Jessica M, Uranga, Selina, Fluckey, James D, O\u27Reilly, Colleen L, Ryan, Patrick, Stanelle, Sean, Humphries, Megan   +6 more
core  

Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: Selumetinib in patients with cholangiocarcinoma

, 2012
background: Cancer cachexia is characterised by skeletal muscle wasting; however, potential for muscle anabolism in patients with advanced cancer is unproven.
Bekaii-Saab, Tanios, Sawyer, Michael B., Shrestha, Suraj, Ghosh, Sunita, Baracos, Vickie E., Doyle, L. Austin, Prado, Carla M.   +6 more
core   +1 more source

Carbonic Anhydrase 12 Protects Endplate Cartilage From Degeneration Regulated by IGF-1/PI3K/CREB Signaling Pathway

Frontiers in Cell and Developmental Biology, 2020
Lumbar intervertebral disc degeneration (IVDD) is the most common cause of low back pain (LBP). Among all the factors leading to IVDD, lumbar cartilage endplate (LCE) degeneration is considered a key factor.
Xing Zhao, Xing Zhao, Panyang Shen, Panyang Shen, Haidong Li, Haidong Li, Haidong Li, Yute Yang, Yute Yang, Jiandong Guo, Jiandong Guo, Shuai Chen, Shuai Chen, Yan Ma, Yan Ma, Jiamin Sheng, Shuying Shen, Shuying Shen, Gang Liu, Gang Liu, Xiangqian Fang, Xiangqian Fang   +21 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats

, 2009
Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old ...
Bos, Cecile, Magne, Hugues, Combaret, Lydie, Julien Averous, Cécile Bos, Isabelle Savary‐Auzeloux, Rieu, Isabelle, Averous, Julien, Hugues Magne, Isabelle Rieu, Peyron, Marie-Agnès, Dardevet, Dominique, Dominique Dardevet, Savary-Auzeloux, Isabelle, Lydie Combaret, M. A. Peyron   +15 more
core   +1 more source

Effects of training on bone metabolism in young athletes

Human Movement, 2021
Antti M.J. Mero, Keijo Häkkinen, Heikki Kyröläinen, Antti A. Mero   +3 more
doaj   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science
Cell proliferation requires anabolic supports. How the cell cycle integrates anabolism remains poorly understood. Herein, it is identified that G1‐phase regulator cell division cycle 20‐like protein 1 (CDH1) coordinates anabolic events to ensure cell ...
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
doaj   +1 more source

Comparable Rates of Integrated Myofibrillar Protein Synthesis Between Endurance-Trained Master Athletes and Untrained Older Individuals

Frontiers in Physiology, 2019
BackgroundAn impaired muscle anabolic response to exercise and protein nutrition is thought to underpin age-related muscle loss, which may be exacerbated by aspects of biological aging that may not be present in older individuals who have undertaken long-
James McKendry, Brandon J. Shad, Benoit Smeuninx, Sara Y. Oikawa, Gareth Wallis, Carolyn Greig, Carolyn Greig, Carolyn Greig, Stuart M. Phillips, Leigh Breen, Leigh Breen, Leigh Breen   +11 more
doaj   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source