Results 31 to 40 of about 29,332 (238)

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal [PDF]

, 2016
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria.
Luchsinger, LL, Busslinger, M, William C. Adams, Meinrad Busslinger, Nyanza J. Rothman, Simone A. Nish, Jeffrey C. Rathmell, Hans-Willem Snoeck, Snoeck, H-W, Larry L. Luchsinger, Chen, Y-H, Rothman, NJ, Radomir Kratchmarov, Adams, WC, Wen-Hsuan W. Lin, Rathmell, JC, Nish, SA, Yen-Hua Chen, William C. Adams, Yen, B, Lin, W-HW, Reiner, SL, Klein, U, Kratchmarov, R, Ulf Klein, Steven L. Reiner, Bonnie Yen   +26 more
core   +1 more source

Testosterone treatment in chronic heart failure. Review of literature and future perspectives

Monaldi Archives for Chest Disease, 2018
Mounting evidence suggests that hormonal deficiencies (HD) have an important role in chronic heart failure (CHF). In particular, androgen depletion is common in men with CHF and is associated with increased morbidity and mortality. This review summarizes
Roberta D'Assante, Lucrezia Piccioli, Pietro Valente, Francesca M. Stagnaro, Alessandra Schiavo, Anna Lombardi, Veronica Panicara, Michele Arcopinto, Giuseppe Vitale, Filippo M. Sarullo, Francesco Giallauria, Alberto M. Marra, Andrea Salzano   +12 more
doaj   +1 more source

Neuroendocrine Balance Index: an Indicator of Metabolic Response to Surgical Stress in Cardiac Surgery

Український журнал серцево-судинної хірургії
Aim. To analyse the dynamics of the Neuroendocrine Balance Index (NEBI = ln(Cortisol/PRL)) during the perioperative period of coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) in order to evaluate its potential as an integrative ...
Lada O. Sobanska, Volodymyr I. Cherniy
doaj   +1 more source

Muscle protein anabolism in type 2 diabetes

, 2016
Purpose of review: Protein anabolism is abnormal in human type 2 diabetes (T2DM). We review studies of anabolic stimuli that identify potential causes.
Gougeon, Réjeanne, Bassil, Maya S.
core   +1 more source

Insights into the Regulation of Indigo Production in an Engineered Escherichia coli Strain via Overexpression of Specific Transporter Genes and Proteomic Analyzes

Foods
Conventional extraction of indigo, a vital natural dye, provides low yields and has a negative environmental impact. However, microbial synthesis has emerged as a sustainable alternative. In this study, we describe the optimization of indigo biosynthesis
Jie Gao, Anni Fang, Tianjiao Meng, Baoguo Sun, Lei Cheng   +4 more
doaj   +1 more source

Time resolved DNA occupancy dynamics during the respiratory oscillation uncover a global reset point in the yeast growth program

Microbial Cell, 2014
The structural dynamics of chromatin have been implicated in the regulation of fundamental eukaryotic processes, such as DNA transcription, replication and repair.
Cornelia Amariei, Rainer Machné, Viktor Stolc, Tomoyoshi Soga, Masaru Tomita, Douglas B. Murray   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intervertebral disc response to stem cell treatment is conditioned by disc state and cell carrier: An ex vivo study

Journal of Orthopaedic Translation, 2017
In vitro and in vivo studies evidenced that mesenchymal stem cells (MSCs) contribute to intervertebral disc (IVD) regeneration by differentiation towards the disc phenotype and matrix synthesis and/or by paracrine signalling to endogenous cells, thereby ...
Marianna Peroglio, Luzia Simone Douma, Tansinee Stephanie Caprez, Milena Janki, Lorin Michael Benneker, Mauro Alini, Sibylle Grad   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source