Results 11 to 20 of about 27,543 (304)

TAp73 promotes anti-senescence-anabolism not proliferation [PDF]

, 2014
TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation.
Niklison-Chirou, MV, Maria Valeria Catani (7651889), Massimiliano Agostini (735918), RUFINI, ALESSANDRO, Maria Victoria Niklison-Chirou (7651886), Alessandro Rufini (3873532), Melino, G, Gerry Melino (735922), Knight, RA, CATANI, MARIA VALERIA, MELINO, GENNARO, Agostini, M, Rufini, A, Niklison Chirou, MV, AGOSTINI, MASSIMILIANO, Richard A. Knight (7585910), Catani, MV   +16 more
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MLYCD mediated Fatty Acids Anabolism Represses Renal Cell Carcinoma Progression

, 2023
To investigate the metabolism of clear cell renal cell carcinoma (ccRCC) and elucidate the effect of malonyl-CoA decarboxylase (MLYCD) on fatty acid (FA) anabolism in ccRCC.
Lijie Zhou
core   +1 more source

Importance of the dietary protein sources to support muscle anabolism in cancer: an expert group opinion

, 2022
This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes.
Phillips S. M., Atherton P. J., Prado C. M., Engelen M. P. K. J., Ravasco P., Laviano A., Lobo D. N., Goncalves T. J. M., Deutz N. E. P., Ford K. L., Arends J.   +10 more
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Insulin signaling requires glucose to promote lipid anabolism in adipocytes. [PDF]

, 2020
Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization based on nutritional status. This is coordinated by insulin, which triggers kinase signaling cascades to modulate numerous metabolic proteins, leading to ...
Francis, Deanne, Soga, Tomoyoshi, Nagarajan, Shilpa R, Cooke, Kristen C., James, David E, Hoy, Andrew J, Giles, Corey, Nagarajan, Shilpa R., Varney, Bianca, Hirayama, Akiyoshi, Weiss, Fiona C., Weiss, Fiona C, Cooney, Gregory J, Huynh, Kevin, Meikle, Peter J, Fazakerley, Daniel J., Suzuki, Kumi, Ikeda, Satsuki, Scalzo, Richard, Humphrey, Sean J., Diaz-Vegas, Alexis, Krycer, James R, Quek, Lake-Ee, Krycer, James R., Cooney, Gregory J., James, David E., Meikle, Peter J., Hoy, Andrew J., Zadoorian, Armella, Humphrey, Sean J, Nelson, Marin E., Shoji, Futaba, Nelson, Marin E, Fazakerley, Daniel J, Cooke, Kristen C   +34 more
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Thermodynamic Limits and Optimality of Microbial Growth

Entropy, 2020
Understanding microbial growth with the use of mathematical models has a long history that dates back to the pioneering work of Jacques Monod in the 1940s.
Nima P. Saadat, Tim Nies, Yvan Rousset, Oliver Ebenhöh   +3 more
doaj   +1 more source

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

Cell Reports, 2018
Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood.
Yen-Hua Chen, Radomir Kratchmarov, Wen-Hsuan W. Lin, Nyanza J. Rothman, Bonnie Yen, William C. Adams, Simone A. Nish, Jeffrey C. Rathmell, Steven L. Reiner   +8 more
doaj   +1 more source

Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway

Frontiers in Nutrition, 2022
γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central nervous system of mammals, it has become a popular dietary supplement
Zhou Heli, Chen Hongyu, Bao Dapeng, Bao Dapeng, Tan Yee Shin, Zhong Yejun, Zhang Xi, Wu Yingying   +7 more
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NAD+ Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy

, 2022
The homeostasis of NAD+ anabolism is indispensable for maintaining the NAD+ pool. In mammals, the mainly synthetic pathway of NAD+ is the salvage synthesis, a reaction catalyzed by nicotinamide mononucleotide adenylyltransferase (NAMPT) and nicotinamide ...
Zhonghua Zhao, Xueguang Liu, Fengxia Li, Nong Zhang, Xue Li, Yankun Li, Hui Li, Qi Chen   +7 more
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A Fenchone Derivative Effectively Abrogates Joint Damage Following Post-Traumatic Osteoarthritis in Lewis Rats

Cells, 2022
Background: In a previous report, we have identified the cannabinoid receptor 2 (CB2) agonist HU308 to possess a beneficial effect in preventing age and trauma-induced osteoarthritis (OA) in mice. The effects of HU308 were largely related to the capacity
Idan Carmon, Reem Smoum, Eli Farhat, Eli Reich, Leonid Kandel, Zhannah Yekhtin, Ruth Gallily, Raphael Mechoulam, Mona Dvir-Ginzberg   +8 more
doaj   +1 more source

Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species

Journal of Lipid Research, 2022
Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not been shown to extensively occur.
Mary T. Doan, Michael D. Neinast, Erika L. Varner, Kenneth C. Bedi, Jr., David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P. Singh, Cholsoon Jang, J. Eduardo Rame, Donita C. Brady, Jordan L. Meier, Kenneth B. Marguiles, Zoltan Arany, Nathaniel W. Snyder   +15 more
doaj   +1 more source