Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13-Sensing Dual-Drug Scaffold. [PDF]
Adv Sci (Weinh)ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhang Z +6 more
europepmc +3 more sources
TAp73 promotes anti-senescence-anabolism not proliferation [PDF]
, 2014 TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation.
Maria Valeria Catani (7651889) +5 more
core +10 more sources
Engineered Cyanobacteria-Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy. [PDF]
Adv Sci (Weinh)An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Yang L +8 more
europepmc +2 more sources
EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma. [PDF]
Adv Sci (Weinh)EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Li Y +9 more
europepmc +2 more sources
Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training [PDF]
, 2008 Purpose of Review: Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging.
Hayes, Alan, Cribb, Paul J
core +6 more sources
Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition. [PDF]
J Cachexia Sarcopenia MuscleBackground: Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC), and negatively impacts patient outcomes.
Arneson-Wissink PC +10 more
europepmc +2 more sources
Importance of the dietary protein sources to support muscle anabolism in cancer: an expert group opinion [PDF]
, 2022 This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes.
Phillips S. M. +10 more
core +2 more sources
MLYCD mediated Fatty Acids Anabolism Represses Renal Cell Carcinoma Progression
, 2023 To investigate the metabolism of clear cell renal cell carcinoma (ccRCC) and elucidate the effect of malonyl-CoA decarboxylase (MLYCD) on fatty acid (FA) anabolism in ccRCC.
Lijie Zhou
core +1 more source
Insulin signaling requires glucose to promote lipid anabolism in adipocytes. [PDF]
, 2020 Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization based on nutritional status. This is coordinated by insulin, which triggers kinase signaling cascades to modulate numerous metabolic proteins, leading to ...
Francis, Deanne +34 more
core +2 more sources
Frontiers in Nutrition, 2022 γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central nervous system of mammals, it has become a popular dietary supplement
Zhou Heli +7 more
doaj +1 more source