Reviewer #1 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis [PDF]
, 2023 openalex +1 more source
Nano Select, EarlyView.Our study presents a novel approach to localized cancer therapy by developing mouse serum albumin (MSA)‐coated paclitaxel (PTX)‐loaded gelatin nanoparticles (MSA@PTX‐loaded GNPs) as a stealth drug delivery system. Given the challenges of nanoparticle‐based chemotherapy, including rapid opsonization and limited drug accumulation at tumor sites, our work
Md. Annur Sadman +10 more
wiley +1 more source
Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley +1 more source
Metabolic symbiosis between oxygenated and hypoxic tumour cells: An agent-based modelling study.
PLoS Computational BiologyDeregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional.
Pahala Gedara Jayathilake +9 more
doaj +1 more source
Effect of barbiturates on anaerobic glycolysis
Folia Pharmacologica Japonica, 1970 As a basis for understanding the mechanism of action of barbiturates, a study of their inhibitory properties on anaerobic glycolysis was undertaken. In starved rats received single intraperitoneal injections of 50 mg/kg pentobarbital or of 100 mg/kg phenobarbital, there was observed a significant decrease in the blood levels of pyruvate and lactate at ...
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Mode of action of vitamin D. The effect of vitamin D deficiency in the rat on anaerobic glycolysis and pyruvate oxidation by epiphyseal cartilage [PDF]
, 1954 P. G. Tulpule, V. N. Patwardhan
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Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Immunometabolic effects of lactate on humoral immunity in healthy individuals of different ages
Nature CommunicationsAging is characterized by chronic systemic inflammation and metabolic changes. We compare the metabolic status of B cells from young and elderly donors and found that aging is associated with higher oxygen consumption rates, and especially higher ...
Maria Romero +6 more
doaj +1 more source
Alternative NAD(P)H dehydrogenase and alternative oxidase: proposed physiological roles in animals [PDF]
, 2019 The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks.
Gospodaryov, Dmytro V. +1 more
core +1 more source
Small Structures, EarlyView.Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou +8 more
wiley +1 more source