Results 71 to 80 of about 70,398 (322)
Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]
, 2016 © The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ +8 more
core +1 more source
Warburg Effect, Glutamine, Succinate, Alanine, When Oxygen Matters
Biology, 2021 Cellular bioenergetics requires an intense ATP turnover that is increased further by hypermetabolic states caused by cancer growth or inflammation. Both are associated with metabolic alterations and, notably, enhancement of the Warburg effect (also known
Frédéric Bouillaud +2 more
doaj +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian +11 more
wiley +1 more source
Medium alkalization due to carbon metabolism is largely responsible for inhibition of bacterial growth by Vibrio cholerae supernatants [PDF]
, 2017 Vibrio cholerae is the causative agent of the diarrheal disease cholera. Many Vibrio species secrete antimicrobial factors, though the identity of such a factor has not been determined for any V. cholerae strain.
Becker, Miranda
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Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. [PDF]
PLoS ONE, 2012 Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation ...
Christophe J De Saedeleer +5 more
doaj +1 more source
Principles for Rigorous Design and Application of Synthetic Microbial Communities
Advanced Science, EarlyView.SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang +21 more
wiley +1 more source
Mass conserved elementary kinetics is sufficient for the existence of a non-equilibrium steady state concentration [PDF]
, 2012 Living systems are forced away from thermodynamic equilibrium by exchange of mass and energy with their environment. In order to model a biochemical reaction network in a non-equilibrium state one requires a mathematical formulation to mimic this forcing.
Fleming, Ronan M. T., Thiele, Ines
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Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.
PLoS Neglected Tropical Diseases, 2012 We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different times after infection with promastigotes of the protozoan parasite Leishmania major.
Imen Rabhi +10 more
doaj +1 more source
Advanced Science, EarlyView.In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang +12 more
wiley +1 more source
Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]
, 2008 The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL +3 more
core +1 more source