Results 51 to 60 of about 395,234 (289)

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Enhancing Surgical Efficiency and Cost‐Effectiveness With TaTME‐Combined Robot‐Assisted Surgery for Lower Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Robot‐assisted rectal surgery (RAS) offers improved dexterity and visualization; however, the high cost of equipment and consumables remains a major challenge for hospital management. At our institution, we have adopted a combined approach using transanal total mesorectal excision (TaTME) for lower rectal cancers, aiming to shorten ...
Takeru Matsuda, Hiroshi Hasegawa, Yasunori Otowa, Masayuki Ando, Tomoaki Aoki, Yasufumi Koterazawa, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji   +9 more
wiley   +1 more source

Patients with newly diagnosed cervical cancer should be screened for anal human papilloma virus and anal dysplasia: Results of a pilot study using a STELLA computer simulation and economic model

Papillomavirus Research, 2018
Background: Women with cervical cancer often have anal human papillomavirus (HPV) infection and anal dysplasia. However, effectiveness of anal HPV screening is unknown. Methods: A dynamic model was constructed using STELLA. Populations are represented as
Eli D. Ehrenpreis, Dylan G. Smith
doaj   +1 more source

Epidemiology of Any and Vaccine-Type Anogenital Human Papillomavirus Among 13-26-Year-Old Young Men After HPV Vaccine Introduction [PDF]

, 2018
PURPOSE: The aims of this study were to determine prevalence of and factors associated with any human papillomavirus (HPV) and vaccine-type HPV among young men after vaccine introduction, stratified by vaccination status.
Bernstein, David I., Brown, Darron A., Chandler, Emmanuel, Ding, Lili, Franco, Eduardo L., Gorbach, Pamina, Kahn, Jessica A., Widdice, Lea E.   +7 more
core   +1 more source

Short Distal Resection Margin Does Not Increase Recurrence Risk After R0 Resection for Rectal Neuroendocrine Tumors: A Single‐Institution Retrospective Study of 208 Patients

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated the impact of distal resection margin (DRM) length on recurrence in 208 patients undergoing surgery for rectal neuroendocrine tumors (NETs). Our findings demonstrate that while oncological safety must unquestionably remain the top priority, a short pathological DRM (< 10 mm) does not increase recurrence risk when R0 resection is ...
Kentaro Sato, Shimpei Matsui, Kaoru Nakano, Yuto Maeda, Tatsuki Noguchi, Takashi Sakamoto, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi   +8 more
wiley   +1 more source

Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model

Microbiology Spectrum
Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, the association between gut microbiota and KRAS mutation in CRC remains enigmatic.
Zigui Huang, Xiaoliang Huang, Yili Huang, Kunmei Liang, Lei Chen, Chuzhuo Zhong, Yingxin Chen, Chuanbin Chen, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Yongzhi Wu, Xianwei Mo, Tang Weizhong, Jungang Liu   +17 more
doaj   +1 more source

Increased Kremen2 predicts worse prognosis in colon cancer

Pathology and Oncology Research, 2023
Background: Colon cancer (CC) is the fifth most prevalent cancer around the globe and poses a major risk to human health. Even though Kremen2 serves as a prognostic indicator in individuals with malignant tumours, its role in evaluating the prognosis of ...
Junxian Long, Junxian Long, Fengyun Cong, Fengyun Cong, Yousheng Wei, Jungang Liu, Jungang Liu, Weizhong Tang, Weizhong Tang   +8 more
doaj   +1 more source

[Anal cancer].

Anales. Universidad Nacional Mayor de San Marcos. Facultad de Medicina, 1967
Although anal cancer is a rare malignancy, chose to develop the theme of this work in an attempt to make a modest contribution to a better understanding of this disease in our environment.
Lamas Ainzuaín, Carlos A., Payet Garreta, Carlos   +1 more
openaire   +2 more sources

Applications of Graphene Quantum Dots in Biomedical Sensors [PDF]

, 2020
Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow ...
Altintas, Zeynep, Mansuriya, Bhargav D.
core   +1 more source

First Successful Regeneration of a Structurally Native‐Like Colon Using a Bioabsorbable Polymer Sheet

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrated that a bioabsorbable polymer sheet (BAPS) can regenerate approximately half the circumference of the colon with native‐like structure and function in an experimental setting. As the model involved immediate closure after perforation and did not reproduce peritonitis, caution is required when considering clinical applicability ...
Junpei Takashima, Mitsuo Miyazawa, Masayasu Aikawa, Daisuke Fujimoto, Hirotoshi Kobayashi   +4 more
wiley   +1 more source