Results 91 to 100 of about 138,045 (265)

Analgesic Activity of Cinnabarinic Acid in Models of Inflammatory and Neuropathic Pain. [PDF]

Front Mol Neurosci, 2022
Notartomaso S, Boccella S, Antenucci N, Ricciardi F, Fazio F, Liberatore F, Scarselli P, Scioli M, Mascio G, Bruno V, Battaglia G, Nicoletti F, Maione S, Luongo L.   +13 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Analgesic and anti-inflammatory evaluations of S-naproxen derivatives in animals models supported by molecular docking simulation studies

Future Journal of Pharmaceutical Sciences
Background In the current study, various S-naproxen derivatives (NDs) were evaluated for their analgesic and anti-inflammatory activities using in vivo models, along with molecular docking studies. The analgesic potential was assessed through acetic acid-
Naveed Muhammad, Faiza Seraj, Uzma, Iffat Akbar, Ubaid Ullah, Abdul Wadood, Amir Zeb, Khalid Mohammed Khan, Omar S. Bahattab, Yahya S. Al-Awthan, Abdur Rauf   +10 more
doaj   +1 more source

Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone. [PDF]

Drug Metab Pharmacokinet, 2022
Wang XM, Wang J, Fokina V, Patrikeeva S, Rytting E, Ahmed MS, La JH, Nanovskaya T.   +7 more
europepmc   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

Preparation and characterization of naproxen solid dispersion using different hydrophilic carriers and in-vivo evaluation of its analgesic activity in mice. [PDF]

Heliyon, 2023
Nupur MA, Rahman MM, Akter K, Hanif KB, Sharna JF, Sarker MS, Ibne Wahed MI.   +6 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity. [PDF]

Pharmaceutics, 2022
Andrei C, Mihai DP, Zanfirescu A, Nitulescu GM, Negres S.   +4 more
europepmc   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies. [PDF]

Drug Des Devel Ther, 2022
Akbar I, Radhakrishnan S, Meenakshisundaram K, Manilal A, Hatamleh AA, Alnafisi BK, Ahamed A, Balasubramani R.   +7 more
europepmc   +1 more source