Advanced Science, EarlyView.MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu +13 more
wiley +1 more source
Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity. [PDF]
Med Princ Pract, 2022 Mizogami M, Tsuchiya H.
europepmc +1 more source
Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off
Advanced Science, EarlyView.Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix +16 more
wiley +1 more source
A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABABR-Coupled N-Type Calcium Channel. [PDF]
Mar Drugs, 2022 Wei Y +9 more
europepmc +1 more source
Advanced Science, EarlyView.Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao +8 more
wiley +1 more source
Advanced Science, EarlyView.Conventional transplantation of human ovarian tissue results in early vascular infiltration that is not sustained over time. Engineering the host‐graft interface by combining multiple, smaller ovarian tissue pieces with a microporous annealed particle (MAP) hydrogel instead supports sustained tissue revascularization and perfusion.
Despina I. Pavlidis +11 more
wiley +1 more source
Importance of piperidone moiety in pharmaceutical chemistry: a review
Journal of Applied Pharmaceutical Research, 2015 Piperidone heterocycle have gained a considerable attention in the field of drug discovery. The wide range of its therapeutic application paved the way to the researchers to insert the nucleus every now and then in diversified pharmacophore, so as to ...
Sourav De +3 more
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Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata. [PDF]
Curr Issues Mol Biol, 2021 Shovo MARB +11 more
europepmc +1 more source
Advanced Science, EarlyView.Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang +12 more
wiley +1 more source
In Vivo and In Silico Analgesic Activity of Ficus populifolia Extract Containing 2-O-β-D-(3',4',6'-Tri-acetyl)-glucopyranosyl-3-methyl Pentanoic Acid. [PDF]
Int J Mol Sci, 2023 Mohammed HA +3 more
europepmc +1 more source