Results 111 to 120 of about 225,759 (311)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Triterpenoid Contents and Anti-Inflammatory Properties of the Methanol Extracts of Ligustrum Species Leaves

Molecules, 2010
Ligustrum (privet) plants are used by Chinese physicians to prevent and cure hepatitis and chronic bronchitis. Three common Ligustrum plant spp., namely Ligustrum lucidum Ait. (LL), L. pricei Hayata (LP) and L. sinensis Lour.
Yung-Ta Lin, Hui Ching, Li-Wei Lin, Chi-Rei Wu, You-Cheng Hseu, Jin-Cherng Lien   +5 more
doaj   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Frontiers in Pharmacology
Background:Pogostemon heyneanus leaves infusions are relevant in ethnopharmacology for treating colds, coughs, headaches, and asthma.Purpose: The essential oil chemical composition of a Pogostemon heyneanus specimen was monthly monitored from October ...
Paulo Vinicius Lima Santos, Paulo Vinicius Lima Santos, Lucas Botelho Jerônimo, Weyda Suyane Campos Ribeiro, Gustavo Moraes Lopes, João Henrique de Castro Leão Neto, Hugo Borges Oliveira da Silva, Pedro Iuri C. da Silva, Pedro Iuri C. da Silva, Renata Cunha Silva, Joyce Kelly da Silva, Jofre Jacob S. Freitas, Rosa Helena V. Mourão, William N. Setzer, José Guilherme S. Maia, Pablo Luis B. Figueiredo, Pablo Luis B. Figueiredo   +16 more
doaj   +1 more source

Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity. [PDF]

Drug Deliv, 2023
Gaber DA, Radwan MA, Alzughaibi DA, Alail JA, Aljumah RS, Aloqla RM, Alkhalifah SA, Abdoun SA.   +7 more
europepmc   +1 more source

Formamidines with antinociceptive and antiinflammatory activities [PDF]

, 1991
Pursuing our investigations on 7-amino-2,3-polymethyleneindole derivatives, a set of 7-(dimethylaminomethylene)-amino-2,3-polymethyleneindoles, together with some other aryl or cycloalkyl substituted formamidines, were prepared and tested for analgesic ...
Boatto, Gianpiero, Carrara, Maria, Cerri, Riccardo, Cima, Lorenzo, Pau, Amedeo, Satta, Margherita, Sparatore, Fabio   +6 more
core  

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Importance of piperidone moiety in pharmaceutical chemistry: a review

Journal of Applied Pharmaceutical Research, 2015
Piperidone heterocycle have gained a considerable attention in the field of drug discovery. The wide range of its therapeutic application paved the way to the researchers to insert the nucleus every now and then in diversified pharmacophore, so as to ...
Sourav De, Subhasis Banerjee, M. Niranjan Babu, C. Navaya Keerithi   +3 more
doaj  

Synthesis, In Silico Logp Study, and In Vitro Analgesic Activity of Analogs of Tetrapeptide FELL. [PDF]

Pharmaceuticals (Basel), 2023
Borisova B, Nocheva H, Gérard S, Laronze-Cochard M, Dobrev S, Angelova S, Petrin S, Danalev D.   +7 more
europepmc   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source