Results 131 to 140 of about 138,045 (265)

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity. [PDF]

Nat Commun
Panel N, Vo DD, Hübner H, Deluigi M, Pach S, Bélair F, Weikert D, Klenk C, Hilge M, Shiva N, Brochu I, Longpré JM, Bällgren F, Saleh A, Hu H, Kapla J, Kampen S, Cabeza de Vaca I, Kihlberg J, Wettschureck N, Sarret P, Plückthun A, Gmeiner P, Carlsson J.   +23 more
europepmc   +1 more source

The Combined Effects of Three Analgesics in Analgesic Activity and Acute Toxicity

YAKUGAKU ZASSHI, 1968
KEIJIRO TAKAGI, ISSEI TAKAYANAGI, SETSUKO KAYAOKA, SUSUMU OKABE, KOKI SHIGENOBU, TAKASHI FUKAO, KOICHIRO KAWASHIMA, FUKUTARO TAGA   +7 more
openaire   +3 more sources

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Cannabidiol-based lipid nanocarriers with analgesic activity. [PDF]

Sci Rep
de Oliveira Sato A, Goulart JPT, Rodrigues TS, Ueira-Vieira C, Bastos LM, Sommerfeld S, Fonseca BB, de Morais Ribeiro LN.   +7 more
europepmc   +1 more source

The Use of Unloader Bracing in the Management of Knee Osteoarthritis: A Modified Delphi Consensus Study

Arthroscopy, EarlyView.
Purpose To develop international expert consensus on the role of unloader bracing in the management of tibiofemoral osteoarthritis (OA) by addressing indications, contraindications, clinical evaluation, perioperative applications, and research priorities using a modified Delphi methodology.
Jonathan T. Super, Luke V. Tollefson, Iain R. Murray, Jorge Chahla, Andrew G. Geeslin, Darren L. Johnson, Ciara M. Stevenson, Robert F. LaPrade, Reykjavik Bracing Consensus Study Group, Robert F. LaPrade, Scott Anderson, Adam W. Anz, Sascha Beck, Andrew S. Bernhardson, Jorge Chahla, Anikar Chhabra, Mark E. Cinque, William M. Cregar, Pieter J. Emans, Scott C. Faucett, Andrew G. Geeslin, Darren L. Johnson, Tobias M. Jung, Patrick W. Kane, Nicholas I. Kennedy, Vickas Khanna, Cory A. Kwong, Christopher M. LaPrade, Martin Lind, Parth Lodhia, Gilbert Moatshe, Iain R. Murray, Johnathan Riboh, Anders Stalman, Ciara M. Stevenson, Wybren A. Van Der Wal, David Wasserstein, Daniel B. Whelan   +37 more
wiley   +1 more source

<i>Schoenoplectus californicus</i> (C.A. Mey.) Soják: Chemical Profile, Antioxidant Capacity, Psychopharmacological Exploration and Analgesic Activity. [PDF]

Mar Drugs
Campos-Florián J, Galliani-Huamanchumo G, Campos-Bazán AV, Chunga-Flores B, Castro-Dionicio I, Villarreal-La Torre VE, Flores-Atoche LF, Gonzales-Mendez L, Ramos-Farfán G, Condor-Goytizolo J, Guevara-Vásquez AM, Soto-Vásquez MR, Rodríguez-Soto JC, Alvarado-García PAA, Sagástegui-Guarniz W, Cabanillas-Amado B.   +15 more
europepmc   +1 more source

Unloader Bracing Is a Biomechanically Rational and Clinically Useful Intervention in Selected Patients With Tibiofemoral Joint Cartilage Pathology: A Modified Delphi Consensus Study

Arthroscopy, EarlyView.
Purpose To establish an international expert consensus on the role of unloader bracing in the management of focal tibiofemoral cartilage lesions using Delphi methodology to inform clinical decision‐making in both nonoperative and operative contexts and identify future research priorities.
Jonathan T. Super, Luke V. Tollefson, Iain R. Murray, Jorge Chahla, Andrew G. Geeslin, Darren L. Johnson, Ciara M. Stevenson, Robert F. LaPrade, Reykjavik Bracing Consensus Study Group, Robert. F. LaPrade, Scott Anderson, Adam. W. Anz, Sascha Beck, Andrew S. Bernhardson, Jorge Chahla, Anikar Chhabra, Mark E. Cinque, William M. Cregar, Pieter J. Emans, Scott C. Faucett, Andrew G. Geeslin, Darren L. Johnson, Tobias. M. Jung, Patrick. W. Kane, Nicholas I. Kennedy, Vickas Khanna, Cory A. Kwong, Christopher M. LaPrade, Martin Lind, Parth. Lodhia, Gilbert Moatshe, Iain R. Murray, Johnathan Riboh, Anders Stalman, Ciara. M. Stevenson, Wybren A. Van Der Wal, David Wasserstein, Daniel B. Whelan   +37 more
wiley   +1 more source

Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice. [PDF]

Blood Adv
Argueta DA, Avalos B, Goel Y, Tran H, Fotio Y, Piomelli D, DiPatrizio NV, Gupta K.   +7 more
europepmc   +1 more source

Vancomycin Soaking Reduces Bacterial Growth During Direct Exposure but Does Not Protect Against Subsequent Graft Contamination: An Ex Vivo and In Vivo Study

Arthroscopy, EarlyView.
Purpose To evaluate, using ex vivo and in vivo controlled contamination models, the antibacterial effect and mechanism of vancomycin presoaking against coagulase‐negative staphylococci. Methods Two contamination models were established. First, allografts were inoculated with Staphylococcus epidermidis (1 × 107 colony‐forming units) and soaked for 5 ...
Hee Jae Huh, Joon Ho Wang, Do Kyung Lee
wiley   +1 more source