Results 151 to 160 of about 138,045 (265)

Spatial Proteomics Identifies Distinct Synovial Microenvironments in Hip and Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a heterogeneous joint disease, yet mechanistic insights derive predominantly from knee OA and are often extrapolated to other joints. We investigated joint‐associated differences in the spatial molecular organization of hip and knee OA synovium.
Peng Xie, Antonia R. Sun, Zhengtan Zheng, Yunkun Qu, Feng Gao, Christina Theodoropoulos, Nicholas Matigian, Zhiyong Li, Ross Crawford, Indira Prasadam   +9 more
wiley   +1 more source

Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice. [PDF]

Front Pharmacol, 2020
Scuteri D, Berliocchi L, Rombolà L, Morrone LA, Tonin P, Bagetta G, Corasaniti MT.   +6 more
europepmc   +1 more source

Arthroscopic Diagnosis and All‐Inside Repair of Meniscofibular Ligament Tear

Arthroscopy Techniques, EarlyView.
Abstract Meniscofibular ligament (MFL) tears are an under‐recognized source of lateral meniscal instability, frequently encountered in association with anterior cruciate ligament injury. Failure to identify and address MFL insufficiency may result in persistent posterolateral pain and meniscal hypermobility despite successful anterior cruciate ligament
Alberto Grassi, Tosca Cerasoli, Vito Gaetano Rinaldi, Claudio Rossi, Giulio Maria Marcheggiani Muccioli, Stefano Zaffagnini   +5 more
wiley   +1 more source

Lateral Extra‐articular Tenodesis With All‐Suture Knotless Anchor

Arthroscopy Techniques, EarlyView.
Abstract Although many patients have had satisfactory outcomes from arthroscopic anterior cruciate ligament reconstruction, persistent rotational instability and graft failure still occur. Therefore, the anterolateral ligament complex has been a newer focus of research.
Lauren Lucina, Sean Tierney, Ronak M. Patel   +2 more
wiley   +1 more source

Valorization of bark extracts from Cerrado and Amazon species: phenolic characterization, antioxidant capacity, and photoprotective potential for circular bioeconomy applications

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Tree bark remains an underexploited source of high‐value‐added phenolic compounds with potential circular bioeconomy applications. This work characterized bark extracts from two species of distinct Brazilian biomes, Stryphnodendron adstringens (Cerrado) and Myrcia eximia (Amazon), obtained with three solvents (ethanol, methanol and acetone ...
Mário Sérgio Lorenço, Danilo José Machado de Abreu, Elesandra da Silva Araujo, Uasmim Lira Zidanes, Laise de Jesus dos Santos, Denisse Concepción Vega Villarruel, Elisângela Elena Nunes Carvalho, Fábio Akira Mori   +7 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment. [PDF]

Rom J Morphol Embryol, 2020
Bărbuceanu F, Roşca EV, Apostol TV, Şeremet OC, Drăghici C, Mihai DP, Negreş S, Niţulescu GM, Bărbuceanu ŞF.   +8 more
europepmc   +1 more source

Safety concerns reported by coroners following fentanyl patch fatalities in England, Wales and Northern Ireland between 1997 and 2024

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To identify safety concerns reported by coroners following fentanyl patch‐related deaths in England, Wales and Northern Ireland, and determine differences in coronial reporting. Methods A systematic case series linking the National Programme on Substance Use Mortality (NPSUM) and the Preventable Deaths Tracker (PDT) (https ...
Eman Mshari, Caroline S. Copeland, Georgia C. Richards   +2 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source