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Association Between Smoking and Opioid Requirement and Pain Intensity in the Early Postoperative Period: A Meta-Analysis. [PDF]
Pain TherSzilagyi IS +6 more
europepmc +1 more source
High-dose opioids in advanced cancer: use factors-retrospective study. [PDF]
BMJ Support Palliat CarePeng W +6 more
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Refractory dependence on opioid analgesics.
Pain, 2019In the present article, we argue that individuals with chronic pain on chronic opioids can develop a complex refractory dependence syndrome which we define here as Opioid Dependence. We further argue that Opioid Dependence is equivalent to the withdrawal/
J. Ballantyne, M. Sullivan, G. Koob
semanticscholar +1 more source
Perspectives on cannabis as a substitute for opioid analgesics.
Pain Management, 2019With the opioid epidemic reaching new heights in the USA, it has become critical to find suitable alternatives to opioids. Cannabis, an antinociceptive, is a strong contender to help patients reduce their opioid usage.
Sara P Khan +2 more
semanticscholar +1 more source
Designing safer analgesics: a focus on μ-opioid receptor pathways
Expert Opinion on Drug Discovery, 2018Introduction: The recent dramatic increase in intentional and unintentional deaths attributed to opioids has refocused attention on the therapeutic ratio (risk–benefit ratio) of opioid analgesics.
J. Pergolizzi +5 more
semanticscholar +1 more source