Results 31 to 40 of about 46,932 (244)
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.This study compared short‐term outcomes of robot‐assisted versus laparoscopic colectomy for colon cancer using 1:1 propensity score matching. Among 218 matched pairs, robot‐assisted colectomy was associated with reduced blood loss, fewer conversions to open surgery, lower overall complication rates, and shorter hospital stays, despite longer operative ...
Akira Inoue +9 more
wiley +1 more source
Frontiers in Medicine, 2021 Background: Pain management is an important priority in the treatment of acute pancreatitis (AP). Current evidence and guideline recommendations are inconsistent on the most effective analgesic protocol.
Wenhao Cai +9 more
doaj +1 more source
Annals of Neurology, EarlyView.Objective Heightened sensitivity to noxious stimulation is a hallmark of chronic pain. Emerging evidence suggests heightened unpleasantness to non‐noxious (eg, auditory) aversive stimulation also characterizes chronic pain, but its magnitude, neural mechanisms, and treatment modifiability remain unknown.
Alina E. C. Panzel +4 more
wiley +1 more source
Nature Communications, 2019 Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and ...
A. Kliewer +8 more
doaj +1 more source
A systematic review of analgesia practices in dogs undergoing ovariohysterectomy [PDF]
Veterinary World, 2018 Aim: This was a systematic review conducted to evaluate the analgesic drugs and techniques used in the management of pain in dogs undergoing ovariohysterectomy.
Willy E. Mwangi +4 more
doaj +1 more source
Osteoarthritis and Cartilage Open, 2021 Objective: To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA). Methods: A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with linkage to ...
Aqila Taqi +2 more
doaj +1 more source
Drug poisonings following bariatric surgery: Case series report
British Journal of Clinical Pharmacology, EarlyView.Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari +3 more
wiley +1 more source
Palliative cancer patients pain reduction methods during opioid epidemic era
Journal of Education, Health and Sport, 2022 Introduction: Opioids are the most commonly used medication in palliative cancer pain treatment due to their proven effectiveness. However, modern anti-pain treatment concentrates not only on analgesics, but simultaneously on the detection of conditions
Natalia Sobańska +9 more
doaj +1 more source