Results 21 to 30 of about 26,307 (265)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo +9 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Analogies in the historical development of IHL (1864–2001)
International Review of the Red CrossAnalogies appear to permeate the entire domain of international humanitarian law (IHL), but as an independent subject of inquiry, they remain largely overlooked within IHL scholarship.
Pauline Lesaffre
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Analogias produzidas por alunos do ensino médio em aulas de física
Revista Brasileira de Ensino de FísicaAnalogias são consideradas recursos didáticos potencialmente úteis, pois servem para mediar o processo de aprendizagem de conceitos/fenômenos/assuntos desconhecidos, mediante o estabelecimento de relações de semelhança e diferença com situações ...
Luciana Bagolin Zambon +1 more
doaj +1 more source
Ciência & Educação, 2003 Vários autores têm refletido sobre o papel das metáforas e das analogias tanto na produção do conhecimento em áreas específicas do saber, quanto na construção do conhecimento no âmbito do desenvolvimento de uma disciplina escolar.
Daniela Frigo Ferraz +1 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Circuit Theory Analysis of Acoustically Coupled Rooms
Revista Elektrón, 2019 A circuit theory approach is presented for the analysis of acoustically coupled spaces. It is based on energy flow and balance with a similar analogy to the one used for solving dynamic thermal systems, where acoustic power is analog to electric current
Federico Miyara
doaj