Results 41 to 50 of about 271,989 (296)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Analogias produzidas por alunos do ensino médio em aulas de física

Revista Brasileira de Ensino de Física
Analogias são consideradas recursos didáticos potencialmente úteis, pois servem para mediar o processo de aprendizagem de conceitos/fenômenos/assuntos desconhecidos, mediante o estabelecimento de relações de semelhança e diferença com situações ...
Luciana Bagolin Zambon, Eduardo Adolfo Terrazzan   +1 more
doaj   +1 more source

Detecting Analogies Unconsciously

Frontiers in Behavioral Neuroscience, 2014
ISSN:1662 ...
Thomas Peter Reber, Thomas Peter Reber, Roger eLuechinger, Peter eBoesiger, Katharina eHenke, Katharina eHenke   +5 more
openaire   +6 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Circuit Theory Analysis of Acoustically Coupled Rooms

Revista Elektrón, 2019
A circuit theory approach is presented for the analysis of acoustically coupled spaces. It is based on energy flow and balance with a similar analogy to the one used for solving dynamic thermal systems, where acoustic power is analog  to electric current
Federico Miyara
doaj  

Analogies in biology textbooks in zoology teaching [PDF]

Investigações em Ensino de Ciências, 2011
The biologic structures of living creatures are of difficult understanding for students, because they are usually unknown by those, in needs of strategic didactics in order to facilitate the student understanding. There are several strategies and methods
Saulo Cézar Seiffert Santos, Augusto Fachín Terán, Maria Clara Silva-Forsberg   +2 more
doaj  

Future teachers’ spontaneous use of analogies in explaining concepts [PDF]

Zbornik Instituta za pedagoška istraživanja, 2018
The use of analogies in teaching can significantly enhance its efficiency. Therefore, it is important for future teachers to master the basic skills of the successful use of analogies even during their pre-service education.
Pavlović Zlatko, Кaurin Sonja
doaj   +1 more source

Formal analogies between gravitation and electrodynamics

, 2008
We develop a theoretical framework that allows us to compare electromagnetism and gravitation in a fully covariant way. This new scenario does not rely on any kind of approximation nor associate objects with different operational meaning as it's sometime
Ashby N., Bel L., Braginsky V. B., Choquet-Bruhat Y., Ciufolini I., Debever R., E. GOULART, F. T. FALCIANO, Forward R. L., Jordan P., Kundt W., Lense J., Mashhoon B., Novello M., Ohanian H. C., Thirring H., Thirring H., Weinberg S.   +17 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

O movimento do sangue no corpo humano: do contexto da produção do conhecimento para o do seu ensino The motion of blood in human body: from the knowledge production context to its teaching

Ciência & Educação, 2004
A partir de um estudo histórico-epistemológico das explicações de Galeno e de Harvey sobre o movimento do sangue no corpo humano, discute-se o papel da História da Ciência na formação de professores.
Nadir Castilho Delizoicov, Maria Helena da Silva Carneiro, Demétrio Delizoicov   +2 more
doaj   +1 more source