Results 61 to 70 of about 222,112 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Labourer la terre, tisser la vie. Éclats d’analogies dans les Andes sud-péruviennes

Journal de la Société des Américanistes, 2012
Plough the earth, weave the life. Sparkles of analogies in the South Peruvian Andes. The ethnographic datum analyzed in this paper concerns the cultivation of an irrigated plot in a peasant community of the South Peruvian Andes (Calca, Cusco).
Ingrid Hall
doaj   +1 more source

Metaphor Types as Strategies for Teaching Regression to Novice Learners

Journal of Statistics and Data Science Education, 2022
Metaphors are well-known tools for teaching statistics to novices. However, educators might overlook metaphor theoretical developments that offer nuanced and testable perspectives on their pedagogical applications.
Dennis Tay
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

AS CONCEPÇÕES DE NATUREZA NOS LIVROS DIDÁTICOS DE CIÊNCIAS

Ensaio Pesquisa em Educação em Ciências
Análise das concepções de natureza dos livros didáticos sob uma perspectiva holística e transformadora. Fomenta discussões entre os profissionais da educação sobre o papel do livro como reprodutor das ideologias dominantes em relação aos recursos ...
Eliecília de Fátima Martins, Gislene Margaret Avelar Guimarães   +1 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

UM ESTUDO DAS ANALOGIAS SOBRE EQUILÍBRIO QUÍMICO NOS LIVROS APROVADOS PELO PNLEM 2007

Ensaio Pesquisa em Educação em Ciências
Este artigo descreve uma análise crítica das analogias apresenta das para o tópico de equilíbrio químico pelos livros de Química aprova dos pelo PNLEM 2007. Foram localizadas oito analogias, sendo uma delas repetida.
Wilmo Ernesto Francisco Junior, Aline Araújo Dias Barros, Viviane Martins Garcia, Ana Carolina Garcia de Oliveira   +3 more
doaj   +1 more source

The Stress Analogy [PDF]

Schizophrenia Bulletin, 1987
The author calls attention to the advantages of using the engineering meaning of stress and strain when applying these terms to describe the effects of social and physical forces on people. Such an analogy opens up the possibility of measuring the amount of damage from excess stresses existing in people, as well as estimating their limits and remaining
openaire   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source