Results 51 to 60 of about 269,729 (275)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Metaphors and Analogies in Pain Management – A Survey of 142 Healthcare Professionals
Indian Journal of PainBackground: Metaphors and analogies are a good way of explaining medical concepts to our patients to help them understand their condition and treatment strategies. Objectives: To find out the opinions of healthcare professionals (HCPs) who manage chronic
Sanjeeva Gupta +3 more
doaj +1 more source
Items of Horse Equipment From Zuevsky Burial Ground of Ananyinо Culture of Cord Ceramics in Udmurtia
Поволжская археология, 2019 The paper has been prepared in connection with the 120th anniversary of the Zuevsky burial ground. Zuevsky (Zuevy Kliuchi I) burial ground is one of the few large Ananyino necropolises in the cis-Kama region, which items are used in cultural and ...
Chernykh Elizaveta M.
doaj +1 more source
Exploring fullerenes and nanotubes in the classroom
Chemistry Teacher International, 2020 Informing citizens about scientific issues in our highly technological world is of major importance. Toward this end, a teaching/learning sequence (TLS) focused on the nanostructures of carbon was developed and implemented in a class of secondary school ...
Velentzas Athanasios, Stavrou Dimitris
doaj +1 more source
Analogical Truth-Conditions for Metaphors [PDF]
, 1994 It has often been said that metaphors are based on analogies, but the nature of this relation has never been made precise. This article rigorously and formally specifies two semantic relations that do obtain between some metaphors and analogies.
Gentner D., Tirrell L.
core +1 more source
Analogical Proportions and Analogical Reasoning - An Introduction [PDF]
, 2017 Analogical proportions are statements of the form “a is to b as c is to d”. For more than a decade now, their formalization and use have raised the interest of a number of researchers. In this talk we shall primarily focus on their modeling in logical settings, both in the Boolean and in the multiple-valued cases.
Prade, Henri, Richard, Gilles
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Repeated Play of Families of Games by Resource-Constrained Players
Games, 2013 This paper studies a repeated play of a family of games by resource-constrained players. To economize on reasoning resources, the family of games is partitioned into subsets of games which players do not distinguish.
Arina Nikandrova
doaj +1 more source
Spacetime dynamics of spinning particles - exact electromagnetic analogies
, 2016 We compare the rigorous equations describing the motion of spinning test particles in gravitational and electromagnetic fields, and show that if the Mathisson-Pirani spin condition holds then exact gravito-electromagnetic analogies emerge.
A. Barnes +32 more
core +1 more source