Results 61 to 70 of about 269,729 (275)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

AS CONCEPÇÕES DE NATUREZA NOS LIVROS DIDÁTICOS DE CIÊNCIAS

Ensaio Pesquisa em Educação em Ciências
Análise das concepções de natureza dos livros didáticos sob uma perspectiva holística e transformadora. Fomenta discussões entre os profissionais da educação sobre o papel do livro como reprodutor das ideologias dominantes em relação aos recursos ...
Eliecília de Fátima Martins, Gislene Margaret Avelar Guimarães   +1 more
doaj   +1 more source

Quantum optical memory protocols in atomic ensembles

, 2018
We review a series of quantum memory protocols designed to store the quantum information carried by light into atomic ensembles. In particular, we show how a simple semiclassical formalism allows to gain insight into various memory protocols and to ...
Abella, Afzelius, Afzelius, Alexander, Allen, Azadeh, Bateman Manuscript Project, Bell, Bennett, Bonarota, Bonarota, Bonarota, Bouguer, Brecht, Brillouin, Bussières, Bustard, Carlson, Chanelière, Chanelière, Chanelière, Clark, Clausen, Clauser, Collins, Cornish, Crisp, Dajczgewand, Damon, Demeter, Eberly, Fetterman, Fisher, Fleischhauer, Fleischhauer, Garwood, Gerasimov, Gisin, Glauber, Gorshkov, Gorshkov, Grangier, Grezes, Grosshans, Gündoğan, Hahn, Hammerer, Hammerer, Hartmann, Hedges, Heshami, Heshami, Hetet, Hosseini, Hosseini, Hosseini, Hosseini, Hétet, Hétet, Jin, Kasapi, Kopvillem, Kraus, Kurnit, Kutluer, Kuznetsova, Lauritzen, Lauritzen, Lauro, Lauro, Le Gouët, Ledingham, Liu, Liu, Longdell, Loudon, Loy, Lvovsky, Ma, Maring, McAuslan, McCall, Minář, Mitsunaga, Moiseev, Moiseev, Moiseev, Moiseev, Mukamel, Nilsson, Novikova, Nunn, Nunn, Pascual-Winter, Phillips, Ralph, Reim, Rostovtsev, Ruggiero, Saglamyurek, Saglamyurek, Sangouard, Sangouard, Scarani, Sekatski, Sekatski, Shakhmuratov, Shaw, Sheremet, Shore, Simon, Simon, Sommerfeld, Spano, Thiel, Tiranov, Usmani, Vitanov, Vivoli, Wootters, Wu, Zhang, Zhong, Zhou, Zhou, Zhou   +125 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Does Contextualism Hinge on A Methodological Dispute? [PDF]

, 2017
In this entry, we provide an overview of some of the methodological debates surrounding contextualism and consider whether they are, in effect, based on an underlying methodological dispute.
Gao, Jie, Gerken, Mikkel, Ryan, Stephen B.   +2 more
core  

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

UM ESTUDO DAS ANALOGIAS SOBRE EQUILÍBRIO QUÍMICO NOS LIVROS APROVADOS PELO PNLEM 2007

Ensaio Pesquisa em Educação em Ciências
Este artigo descreve uma análise crítica das analogias apresenta das para o tópico de equilíbrio químico pelos livros de Química aprova dos pelo PNLEM 2007. Foram localizadas oito analogias, sendo uma delas repetida.
Wilmo Ernesto Francisco Junior, Aline Araújo Dias Barros, Viviane Martins Garcia, Ana Carolina Garcia de Oliveira   +3 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Teaching Life Sciences to English second language learners: what do teachers do?

South African Journal of Education, 2011
South Africa has eleven official languages and legally learners receive tuition in their mother tongue until the end of Grade 3. From then on teachers are required to teach through the medium of English or Afrikaans.
Johanna G Ferreira
doaj   +2 more sources