Analytical Quality by Design Driven Development and Validation of UV-Visible Spectrophotometric Method for Quantification of Xanthohumol in Bulk and Solid Lipid Nanoparticles. [PDF]
Turk J Pharm Sci, 2023 Vancha H +6 more
europepmc +1 more source
Protein corona characterization through analytical quality-by-design
, 2019 After administration of nanoparticles (NP) into biological fluids, the NP may interact with surrounding biomolecules like proteins. Those interactions can then cause protein corona (PC) that affect the physicochemical and biological properties of NP.
Deleforterie, Jeanne, Bastogne, Thierry
openaire +1 more source
Applied business analytics approach to IT projects – Methodological framework [PDF]
, 2017 The design and implementation of a big data project differs from a typical business intelligence project that might be presented concurrently within the same organization. A big data initiative typically triggers a large scale IT project that is expected
Ivanov, Penko, Zlatev, Vladimir
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The Psycho-sensorial Value of the Food Products a Provocative Component in Purchase Decision [PDF]
The psycho-sensorial value is a specific, complex and determinant concept of the food products that is reflected by means of psycho-sensorial properties such as: shape, size, aspect, colour, taste, smell, fragrance, bouquet, density, clarity.
Magdalena Bobe, Roxana Procopie
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
MoleculesIn response to recent regulatory guidelines, including ICH (International Council for Harmonisation) Q2 (R2) and Q14, we developed a UPLC-ELSD method to quantify Medium-Chain Triglycerides (MCTs) in Labrafac™ WL 1349 for nanoemulsion applications.
Alessio Gaggero +5 more
doaj +1 more source
Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms. [PDF]
BMC Chem, 2023 Magdy G +4 more
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Analytical Quality by Design (AQbD) Approach to the Development of In Vitro Release Test for Topical Hydrogel. [PDF]
Pharmaceutics, 2022 Szoleczky R +6 more
europepmc +1 more source