Results 111 to 120 of about 1,038 (200)
AnalyticaImpurity profiling is of significant analytical and regulatory importance, particularly in the context of lifecycle quality management. A robust chaotropic chromatography method was developed for the determination of olanzapine and its two oxidative ...
Milena Rmandić +5 more
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Green Chemistry Letters and ReviewsQuality-by-Design (QbD) and Green Analytical Chemistry (GAC) are used to develop a sustainable RP-UPLC method for detecting Nirogacestat hydrobromide (NGS) in bulk and pharmaceutical formulations.
Vanga Mohan Goud +4 more
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Analytical Quality by Design (AQbD): Principles, Tools and Case Studies
Quality by Design is a systematic approach used in pharmaceutical development that builds product quality into the formulation and manufacturing processes from the outset. Although its adoption is increasing within the generic drug industry, many professionals are still not deeply familiar with its principles or terminology.
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Discover ChemistryAn accurate, precise, robust, and green RP-HPLC method was developed for assessment of three antiviral medications, namely Abacavir (ABA), Lamivudine (LAMI), and Zidovudine (ZIDO) in combined pharmaceutical dosage form by Analytical Quality by Design ...
Divyesh Vanparia +2 more
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Optimization of green LC-MS method for rosuvastatin and teneligliptin using AQbD chemometric approach [PDF]
Background: Rosuvastatin combined with Teneligliptin formulation is commonly used in the treatment of Diabetic dyslipidaemia. However, only a few analytical methods have been published for the examination of this drug in a synthetic mixture or in a ...
Hemnath Elango, S R Aswathy
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Design Approach in RP-HPLC Method Development and Validation of Nirogacestat in its Pure and Pharmaceutical Dosage Form [PDF]
Aim: Nirogacestat is a selective γ-secretase inhibitor approved by the USFDA for the treatment of Desmoid Tumour. Objective: In this study, a reversed-phase high performance liquid chromatography (RP-HPLC) method was designed to analyze the concentration
Chandrasekar R, Sivagami B, Roshini M, Kumanan R, Sudha S, Sai Koteswar Sharma
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Ion-pair RP-HPLC strategy for resolving polarity-mismatched APIs in sustained-release capsules: an AQbD-driven mechanistic and statistical optimization [PDF]
A robust ion-pair reversed-phase HPLC (RP-HPLC) method was developed for the simultaneous separation of pseudoephedrine sulfate (PSE) and loratadine (LOR) in sustained-release capsules.
Leo Anggara, Satrialdi, Sophi Damayanti
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SeparationsThe Analytical Quality by Design (AQbD) concept was adopted to establish a quantitative analysis of multi-components with a single marker (QAMS) method for industrial lanolin alcohol, targeting cholesterol, lanosterol, and 24,25-dihydrolanosterol.
Kaidierya Abudureheman +3 more
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Chemometric Approaches for Sustainable Pharmaceutical Analysis Using Liquid Chromatography [PDF]
Chemometrics, which applies mathematical and statistical methods to aid in experimental design, data analysis, and process optimization, is gaining more importance.
Aboushady, Dina +6 more
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Protein corona characterization through analytical quality-by-design [PDF]
, 2019 Présentation PosterNational audienceAfter administration of nanoparticles (NP) into biological fluids, the NP may interact with surrounding biomolecules like proteins.
Bastogne, Thierry, Deleforterie, Jeanne
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