Results 91 to 100 of about 78,527 (313)

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

eLife, 2020
During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for timely ...
Babhrubahan Roy, Simon JY Han, Adrienne Nicole Fontan, Ajit P Joglekar   +3 more
doaj   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Asymmetrical inheritance of plasmids depends on dynamic cellular geometry and volume exclusion effects [PDF]

, 2015
The asymmetrical inheritance of plasmid DNA, as well as other cellular components, has been shown to be involved in replicative aging. In Saccharomyces cerevisiae, there is an ongoing debate regarding the mechanisms underlying this important asymmetry. Currently proposed models suggest it is established via diffusion, but differ on whether a diffusion ...
arxiv   +1 more source

Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]

, 2004
Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core   +2 more sources

Reconstitution of anaphase DNA bridge recognition and disjunction [PDF]

Nature Structural & Molecular Biology, 2018
Faithful chromosome segregation requires that the sister chromatids be disjoined completely. Defective disjunction can lead to the persistence of histone-free threads of DNA known as ultra-fine bridges (UFBs) that connect the separating sister DNA molecules during anaphase.
Kata Sarlós, Andreas S. Biebricher, Anna H. Bizard, Julia A. M. Bakx, Anna G. Ferreté-Bonastre, Mauro Modesti, Manikandan Paramasivam, Qi Yao, Erwin J. G. Peterman, Gijs J. L. Wuite, Ian D. Hickson   +10 more
openaire   +7 more sources

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Advanced Science, EarlyView.
This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng, Yunhao Pan, Fengyuan Qian, Diya Liu, Danrong Ye, Bolin Yu, Seng Zhong, Wenfang Zheng, Xuehui Wang, Baian Zhou, Yuying Wang, Lin Fang   +11 more
wiley   +1 more source

Holocentric Chromosomes of Luzula elegans Are Characterized by a Longitudinal Centromere Groove, Chromosome Bending, and a Terminal Nucleolus Organizer Region [PDF]

, 2011
The structure of holocentric chromosomes was analyzed in mitotic cells of Luzula elegans. Light and scanning electron microscopy observations provided evidence for the existence of a longitudinal groove along each sister chromatid.
A. Houben, Albertson DG, Albertson DG, Allshire RC, Bizzaro D, Black BE, Black BE, Black BE, Braselton JP, Buchwitz BJ, Carroll CW, Cattani MV, Comings DE, Cox AV, da Silva CR, Dernburg AF, Desai A, E. Schroeder-Reiter, Earnshaw WC, Fuchs J, Fukova I, G. Wanner, Gerlach WL, Guerra M, Guerra M, Houben A, Howe M, K. Kumke, K. Nagaki, Kato A, Kitagawa R, L. Ma, M. Murata, Maddox PS, Madej A, Mandakova T, Mandrioli M, Martin R, Moore LL, Nagaki K, Papeschi AG, Pimpinelli S, Raska I, Rebagliati PJ, S. Heckmann, Schneider MC, Schroeder-Reiter E, Sekulic N, Sullivan KF, Valarik M, Vanzela ALL, Vanzela ALL, Viera A, Wanner G   +53 more
core   +1 more source

CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.

Cancer Research, 2015
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacologic targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells.
Shanhu Hu, A. Danilov, Kristina M. Godek, B. Orr, L. Tafe, J. Rodriguez-Canales, C. Behrens, B. Mino, C. Moran, V. Memoli, L. Mustachio, F. Galimberti, S. Ravi, A. DeCastro, Yun Lu, David J. Sekula, A. Andrew, I. Wistuba, S. Freemantle, D. Compton, E. Dmitrovsky   +20 more
semanticscholar   +1 more source

Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis. [PDF]

PLoS Genetics, 2008
Several meiotic processes ensure faithful chromosome segregation to create haploid gametes. Errors to any one of these processes can lead to zygotic aneuploidy with the potential for developmental abnormalities.
Tom A Hartl, Sarah J Sweeney, Peter J Knepler, Giovanni Bosco   +3 more
doaj   +1 more source

The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma

Advanced Science, EarlyView.
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan, Xuechao Wu, Jinxu Zhou, Weiqi Wu, Yuanliang Cao, Cuiping Sun, Zheng Li, Zhicheng Gong, Hong Tang, Qilin Li, Junsheng Chu, Qing Wang, Kaisa Cui, Xiaojie Lu   +13 more
wiley   +1 more source