Results 91 to 100 of about 52,438 (267)

Covalent Inhibition of the Peptidyl‐Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2‐OS Cells

PROTEOMICS, EarlyView.
ABSTRACT Peptidyl‐prolyl isomerase, NIMA‐interacting protein 1‐(Pin1) catalyses the cis–trans interconversion of the inflexible bond between serine or threonine residues and proline at the +1 position (pSer/pThr‐Pro). Although initially discovered as an essential regulator of cell division, Pin1 has since been identified as a regulator of many ...
Scott E. Roffey, Owen Hovey, Kristina Jurcic, Kun Ping Lu, Xiao Zhen Zhou, David W. Litchfield   +5 more
wiley   +1 more source

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

Aging Cell, EarlyView.
In this work, we found that birds with similar lifespans exhibit convergent evolution in specific genes, suggesting that shared evolutionary pressures shape the genetic basis of lifespan similarity across species. By investigating protein–protein interactions across genes evolving convergently in long‐ and short‐lived species, we identified a network ...
Mirko Martini, Giovanni Piccinini, Liliana Milani, Mariangela Iannello   +3 more
wiley   +1 more source

Real time observation of anaphase in vitro. [PDF]

Proceedings of the National Academy of Sciences, 1996
We used digital fluorescence microscopy to make real-time observations of anaphase chromosome movement and changes in microtubule organization in spindles assembled in Xenopus egg extracts. Anaphase chromosome movement in these extracts resembled that seen in living vertebrate cells.
Arshad Desai, Edward D. Salmon, Andrew W. Murray   +2 more
openaire   +3 more sources

KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death

Cancer Science, EarlyView.
Bioinformatic analysis of 42 KLHL family genes identified KLHL5 as a potential prognostic biomarker for colorectal cancer (CRC), with higher expression in the common molecular subtype (CMS) 4 CRC, which is characterized by poorer overall and recurrence‐free survival rates compared to other CMS groups. KLHL5 immunohistochemical analysis was performed on
Kyosuke Habu, Yosuke Matsuoka, Hiromi Hiyoshi, Jun Nakayama, Katsuya Watanabe, Sota Tate, Tomohisa Sakaue, Junko Murai, Konomu Uno, Hirotada Nishie, Eiji Kubota, Hiromi Kataoka, Takashi Joh, Yuji Watanabe, Taro Oshikiri, Shigeki Higashiyama   +15 more
wiley   +1 more source

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

Cell Proliferation, EarlyView.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao, Yongzhi Cao, Hongbin Liu   +8 more
wiley   +1 more source

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics

Epilepsia, EarlyView.
Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen, Ronny Mohren, Micca Neusinger, Tobias A. Dancker, Michiel Vandenbosch, Jan Beckervordersandforth, Benjamin Balluff, Rianna P. Van der Hel, Olaf E. M. G. Schijns, Govert Hoogland, Kim Rijkers, Berta Cillero‐Pastor, ACE epilepsy surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen–Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Ilse van Straaten, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +33 more
wiley   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

PLoS Genetics, 2018
It is widely accepted in eukaryotes that the cleavage furrow only initiates after mitosis completion. In fission yeast, cytokinesis requires the synthesis of a septum tightly coupled to cleavage furrow ingression.
Juan Carlos G Cortés, Mariona Ramos, Mami Konomi, Iris Barragán, M Belén Moreno, María Alcaide-Gavilán, Sergio Moreno, Masako Osumi, Pilar Pérez, Juan Carlos Ribas   +9 more
doaj   +1 more source

Phytochrome A is required for light‐inhibited germination of Aethionema arabicum seed

New Phytologist, EarlyView.
Summary The germination of most seeds is influenced by the duration, intensity, and quality of light. The seeds of the model plant Arabidopsis are positive photoblastic and require light to germinate. The germination of negative photoblastic seeds is inhibited by white light.
Zsuzsanna Mérai, Fei Xu, Anita Hajdu, László Kozma‐Bognár, Liam Dolan   +4 more
wiley   +1 more source

Forces on chromosomal DNA during anaphase

Biophysical Journal, 1996
In the course of anaphase, the chromosomal DNA is submitted to the traction of the spindle. Several physical problems are associated with this action. In particular, the sister chromatids are generally topologically intertwined at the onset of anaphase, and the removal of the intertwinings results from a coupling between the enzymatic action of type II
Gérard Jannink, Bertrand Duplantier, Jean-Louis Sikorav   +2 more
openaire   +3 more sources