Results 91 to 100 of about 66,778 (245)

RECQ4 restricts non-interfering crossover formation to fine-tune meiotic recombination rates in rice. [PDF]

Plant Biotechnol J
Summary Crop breeding fundamentally depends on meiotic crossovers (COs) to reshuffle genetic material and integrate favourable alleles into elite cultivars. Recombination frequency is of paramount importance in this process. Higher recombination rates enhance the probability of breaking linkage drag and generating novel allelic combinations.
Li Y, You H, Cheng X, Wang B, Zhao Y, Chen J, Cao L, Wen M, Zhang Y, Chen Z, Luo Q, Cheng Z.   +11 more
europepmc   +2 more sources

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Aberrant meiotic behavior in Agave tequilana Weber var. azul

BMC Plant Biology, 2002
Background Agave tequilana Weber var. azul, is the only one variety permitted by federal law in México to be used for tequila production which is the most popular contemporary alcoholic beverage made from agave and recognized worldwide.
Rodríguez-Garay Benjamin, Ruvalcaba-Ruiz Domingo   +1 more
doaj   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, EarlyView.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, EarlyView.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.

PLoS Genetics, 2020
In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido, Mohammed Bourouh, Éric Bonneil, Pierre Thibault, Andrew Swan, Vincent Archambault   +5 more
doaj   +1 more source

HROB Induces Lung Adenocarcinoma Progression via ZC3HC1‐CCNB1 Axis Regulation and Cell Cycle Dysregulation

Cancer Science, EarlyView.
We have uncovered a novel mechanism by which HROB modulates cell proliferation in lung adenocarcinoma. Our findings suggest that HROB recruits ZC3HC1 and mediates its de‐phosphorylation at Ser354, which in turn promotes K27‐linked ubiquitination of CCNB1, leading to its proteasomal degradation.
Zhe Zhang, Cheng Wang, Yuanwei Guo, Zhenyu Zhao, Zhi Yang, Shouzhi Xie, Xinhang Hu, Xingchun Huang, Yupeng Jiang, Bing Xiao, Li Wang, Fenglei Yu, Bin Wang   +12 more
wiley   +1 more source

TP‐0903 Suppresses Aurora A–PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome‐Derived Cell Line

Cancer Science, EarlyView.
TP‐0903 exerts the antitumor effects through diverse cell‐specific mechanisms, including apoptosis, ferroptosis, and cell cycle disruption. These insights underline the potential of TP‐0903 as a therapeutic agent for hematological malignancies and emphasize the need for further research to fully elucidate the molecular targets of TP‐0903 and optimize ...
Tomoko Kimura‐Hyoda, Mikuri Ryu, Ryosuke Yuta, Saori Fukumoto, Kentaro Hosokawa, Hisayuki Yao, Yoko Yasuda, Koichi Miura, Kaoru Tohyama, Fumio Arai, Takeshi Uchiumi   +10 more
wiley   +1 more source

Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly

Cancer Science, EarlyView.
Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso, Hironori Inaba, Masato T. Kanemaki, Esteban C. Gabazza, Hidemi Toyoda, Masahiro Hirayama, Hidemasa Goto   +6 more
wiley   +1 more source

ACTION SPECTRA FOR MITOTIC SPINDLE DESTRUCTION AND ANAPHASE DELAY FOLLOWING IRRADIATION OF THE CYTOPLASM WITH AN ULTRAVIOLET MICROBEAM* [PDF]

, 1967
Darrell Q. Brown, Raymond E. Zirkle
openalex   +1 more source