Results 91 to 100 of about 154,428 (289)

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Cytoskeleton, EarlyView.
ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley, Taylor Mahoney, Christian Pagán Medina, Parsa Zareiesfandabadi, Matthew B. Rapp, Mastawal Tirfe, Sharonda J. LeBlanc, Meredith D. Betterton, Mary Williard Elting   +8 more
wiley   +1 more source

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase. [PDF]

PLoS ONE, 2016
Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer.
Judit Pampalona, Emanuele Roscioli, William T Silkworth, Brent Bowden, Anna Genescà, Laura Tusell, Daniela Cimini   +6 more
doaj   +1 more source

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]

, 2011
During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson, Anderson, Anderson, Antonin, Baumann, Belgareh, Bodoor, Burke, Chaudhary, Comings, Crisp, Cronshaw, Doucet, Drin, Dultz, Dultz, D’Angelo, Ehrlich, Ellenberg, Ferko, Franz, Gillespie, Goldberg, Haraguchi, Haraguchi, Haraguchi, Harel, Hetzer, Kiseleva, Kremer, Lei Lu, Lu, Macaulay, Mark S. Ladinsky, Mastronarde, Mastronarde, Maul, Patel, Puhka, Rabut, Rasala, Rasala, Rotem, Sheehan, Tomas Kirchhausen, Voeltz, Walther, Yang, Zuccolo   +48 more
core   +4 more sources

PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes, Norman R. Groves, Jessica Z. Li, Lily N. Thompson, Brian J. Smith, Aman Y. Husbands, Iris Meier   +6 more
wiley   +1 more source

Separase prevents genomic instability by controlling replication fork speed [PDF]

, 2016
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco, Palumbo, Elisa, Camerini, Serena, D'Alessio, Barbara, Quarantotti, Valentina, Casella, Maria Luisa, Rizzo, Ilaria Maria, Cukrov, Dubravka, Delia, Domenico, Russo, Antonella, Crescenzi, Marco, Musio, Antonio   +11 more
core   +4 more sources

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, EarlyView.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source

The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

Nature Communications, 2020
The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin
Sang-Min Jang, Jenny F. Nathans, Haiqing Fu, Christophe E. Redon, Lisa M. Jenkins, Bhushan L. Thakur, Lőrinc S. Pongor, Adrian M. Baris, Jacob M. Gross, Maura J. OʹNeill, Fred E. Indig, Steven D. Cappell, Mirit I. Aladjem   +12 more
doaj   +1 more source

An Orthogonal Way of Writing the Tubulin Code

Cytoskeleton, EarlyView.
ABSTRACT The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells.
Vicente Jose Planelles‐Herrero, Emmanuel Derivery   +1 more
wiley   +1 more source