Results 61 to 70 of about 64,230 (279)

The syncytial Drosophila embryo as a mechanically excitable medium [PDF]

PLoS ONE 8, e77216 (2013), 2013
Mitosis in the early syncytial Drosophila embryo is highly correlated in space and time, as manifested in mitotic wavefronts that propagate across the embryo. In this paper we investigate the idea that the embryo can be considered a mechanically-excitable medium, and that mitotic wavefronts can be understood as nonlinear wavefronts that propagate ...
arxiv   +1 more source

Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly. [PDF]

, 2018
Mitotic spindle disassembly after chromosome separation is as important as spindle assembly, yet the molecular mechanisms for spindle disassembly are unclear.
Avunie-Masala, Buvelot, Cheeseman, Chen, Cleary, Cormier, Cottingham, David G. Drubin, Foiani, Fridman, Georjana Barnes, Gruneberg, Hoyt, Hoyt, Hsu, Itziar Ibarlucea-Benitez, Jaqaman, Kang, Khmelinskii, Kotwaliwale, Longtine, Luke S. Ferro, Morawska, Movshovich, Murata-Hori, Nakajima, Nakajima, Nicholas, Nishimura, Norden, Petersen, Reck-Peterson, Saunders, Saunders, Shannon, Straight, Tarantino, Thomas, Varga, Woodruff, Woodruff, Xing, Zhang, Zimniak   +43 more
core   +1 more source

A Wee1 checkpoint inhibits anaphase onset [PDF]

Journal of Cell Biology, 2013
Cdk1 drives both mitotic entry and the metaphase-to-anaphase transition. Past work has shown that Wee1 inhibition of Cdk1 blocks mitotic entry. Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing Cdk1 phosphorylation and activation of the mitotic form of the anaphase-promoting complex/
Elizabeth C. Williams, Adam D. Rudner, Stéphanie L. Girard, Jean-Sebastien Deneault, Carole Doré, Erin K. Kennedy, Noel Lianga, Sophie Pilon   +7 more
openaire   +3 more sources

Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast. [PDF]

PLoS Genetics, 2015
Substrate dephosphorylation by the cyclin-dependent kinase (Cdk)-opposing phosphatase, Cdc14, is vital for many events during budding yeast mitotic exit.
Molly Godfrey, Thomas Kuilman, Frank Uhlmann   +2 more
doaj   +1 more source

Cell cycle: Oiling the gears of anaphase [PDF]

Current Biology, 1998
The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.
Peter K. Jackson, Dieter A. Wolf
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Mitotic Exit Function of Polo-like Kinase Cdc5 Is Dependent on Sequential Activation by Cdk1

Cell Reports, 2016
To complete mitosis, Saccharomyces cerevisiae needs to activate the mitotic phosphatase Cdc14. Two pathways contribute to Cdc14 regulation: FEAR (Cdc14 early anaphase release) and MEN (mitotic exit network).
Jose-Antonio Rodriguez-Rodriguez, Yolanda Moyano, Soraya Játiva, Ethel Queralt   +3 more
doaj   +1 more source

Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes. [PDF]

PLoS ONE, 2007
The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Patricia E Rischitor, Karen M May, Kevin G Hardwick   +2 more
doaj   +1 more source

Contrasting roles of condensin I and condensin II in mitotic chromosome formation [PDF]

, 2012
© 2012. Published by The Company of Biologists LtdIn vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes.
Abe, Adams, Adolph, Anderson, Baron, Baumann, Belmont, Bernad, Buerstedde, Chan, Cooke, Csankovszki, Csankovszki, D'Ambrosio, Dej, Earnshaw, Earnshaw, Fazzio, Fedorov, Gasser, Gerlich, Gossen, Graumann, Gustafsson, Hagstrom, Hilwig, Hirano, Hirano, Hirano, Hirota, Hudson, Hudson, Hudson, Jaqaman, Kelly, Kireeva, Kurasawa, Lipp, Maeshima, Markaki, Moser, Murnion, Ohta, Oliveira, Ono, Ono, Paulson, Pertile, Ribeiro, Ruchaud, Saitoh, Samejima, Samoshkin, Savvidou, Shintomi, Siddiqui, Spence, Stear, Strukov, Strunnikov, Takemoto, Vagnarelli, Volkov, Wang, Wang, Watrin, Wignall, Yamagishi, Yanagida, Yoshimura   +69 more
core   +2 more sources

Spatial control of the anaphase-telophase transition [PDF]

Cell Cycle, 2014
The ultimate goal of mitosis is to physically separate the entire set of duplicated chromosomes in order to propagate the genetic information during cell division. The perpetuation of a faithful maintenance of the genome integrity can only be guaranteed by the existence of multiple cell cycle checkpoints.1 In particular, mitosis is a highly regulated ...
Olga Afonso, Irina Matos, Helder Maiato
openaire   +3 more sources