Results 71 to 80 of about 167,277 (315)

Spatial control of the anaphase-telophase transition [PDF]

Cell Cycle, 2014
The ultimate goal of mitosis is to physically separate the entire set of duplicated chromosomes in order to propagate the genetic information during cell division. The perpetuation of a faithful maintenance of the genome integrity can only be guaranteed by the existence of multiple cell cycle checkpoints.1 In particular, mitosis is a highly regulated ...
Olga Afonso, Irina Matos, Helder Maiato
openaire   +3 more sources

Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]

, 2011
During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Arumugam, Prakash, Kerr, Gary W., Millar, Jonathan B. A., Petronczki, Mark, Sarkar, Sourav, Tibbles, Katherine L.   +5 more
core   +3 more sources

Cell cycle: Oiling the gears of anaphase [PDF]

Current Biology, 1998
The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.
Peter K. Jackson, Dieter A. Wolf
openaire   +3 more sources

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

Advanced Science, EarlyView.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A. Tainer, Yin Shi, Zu Ye, Xiangdong Cheng   +23 more
wiley   +1 more source

Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes. [PDF]

PLoS ONE, 2007
The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Patricia E Rischitor, Karen M May, Kevin G Hardwick   +2 more
doaj   +1 more source

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly [PDF]

, 2011
During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.
Anderson, Anderson, Anderson, Antonin, Baumann, Belgareh, Bodoor, Burke, Chaudhary, Comings, Crisp, Cronshaw, Doucet, Drin, Dultz, Dultz, D’Angelo, Ehrlich, Ellenberg, Ferko, Franz, Gillespie, Goldberg, Haraguchi, Haraguchi, Haraguchi, Harel, Hetzer, Kiseleva, Kremer, Lei Lu, Lu, Macaulay, Mark S. Ladinsky, Mastronarde, Mastronarde, Maul, Patel, Puhka, Rabut, Rasala, Rasala, Rotem, Sheehan, Tomas Kirchhausen, Voeltz, Walther, Yang, Zuccolo   +48 more
core   +4 more sources

The role of phosphorylation in the elasticity of the tethers that connect telomeres of separating anaphase chromosomes

Nucleus, 2020
Elastic tethers, connecting telomeres of all separating anaphase chromosome pairs, lose elasticity when they lengthen during anaphase. Treatment with phosphatase inhibitor CalyculinA causes anaphase chromosomes to move backwards after they reach the ...
Emma Kite, Arthur Forer
doaj   +1 more source

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]

, 2009
FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during ...
Angus I. Lamond, Bastiaens, Belmont, Choi, Cushman, David G. Norman, David Llères, Elgin, Förster, Gerlich, Gilbert, Grewal, Grunstein, Huisinga, Huynh, John James, Kanda, Keppler, Kimura, Kimura, Kruhlak, Lakowicz, Lippincott-Schwartz, Llères, Luger, Luger, Luger, Misteli, Mora-Bermúdez, Mora-Bermúdez, Perche, Phair, Platani, Rhodes, Robinett, Sam Swift, Shaner, Shaner, Shav-Tal, Strukov, Swedlow, Taddei, Telford, Treanor, Tremethick, Trinkle-Mulcahy, Turner, Tóth, Vagnarelli, van Munster, Wallrabe, Wolffe, Wouters   +52 more
core   +5 more sources

Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans

Journal of Cell Biology, 2015
In early C. elegans embryos, the kinetochore-localized BUB- 1/BUB-3 complex promotes anaphase onset independently of its roles in spindle checkpoint signaling and chromosome alignment.
Taekyung Kim, Mark W. Moyle, Pablo Lara-Gonzalez, Christian O. de Groot, K. Oegema, A. Desai   +5 more
semanticscholar   +1 more source