Results 71 to 80 of about 154,428 (289)

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

eLife, 2020
During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for timely ...
Babhrubahan Roy, Simon JY Han, Adrienne Nicole Fontan, Ajit P Joglekar   +3 more
doaj   +1 more source

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. [PDF]

PLoS ONE, 2009
Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis ...
William T Silkworth, Isaac K Nardi, Lindsey M Scholl, Daniela Cimini   +3 more
doaj   +1 more source

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Meiotic behavior of small chromosomes in maize

Frontiers in Plant Science, 2013
The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine and then separate at anaphase I. At anaphase II, sister chromatids separate.
James A. Birchler, Fangpu eHan
doaj   +1 more source

Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]

, 2011
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara, Boudolf, Véronique, De Jaeger, Geert, De Veylder, Lieven, De Wit, Kevin, Heyman, Jefri, Koncz, Csaba, Lessa Alvim Kamei, Claire, Van Den Daele, Hilde, Verkest, Aurine   +9 more
core   +2 more sources

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry

Nature Communications, 2020
Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase
Zhe Wei, Jessica Greaney, Wei-Guo Nicholas Loh, Hayden Anthony Homer   +3 more
doaj   +1 more source

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]

, 2009
FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during ...
Angus I. Lamond, Bastiaens, Belmont, Choi, Cushman, David G. Norman, David Llères, Elgin, Förster, Gerlich, Gilbert, Grewal, Grunstein, Huisinga, Huynh, John James, Kanda, Keppler, Kimura, Kimura, Kruhlak, Lakowicz, Lippincott-Schwartz, Llères, Luger, Luger, Luger, Misteli, Mora-Bermúdez, Mora-Bermúdez, Perche, Phair, Platani, Rhodes, Robinett, Sam Swift, Shaner, Shaner, Shav-Tal, Strukov, Swedlow, Taddei, Telford, Treanor, Tremethick, Trinkle-Mulcahy, Turner, Tóth, Vagnarelli, van Munster, Wallrabe, Wolffe, Wouters   +52 more
core   +5 more sources

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity

Animal Models and Experimental Medicine, EarlyView.
Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang, Meng Lv, Haidan Fan, Yonghua Shi, Tao Wang, Penghao Wang, Xiaolong Yuan, Fei Gao, Bin Ma   +8 more
wiley   +1 more source