High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1
Advanced Science, EarlyView.This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng +11 more
wiley +1 more source
Meiotic behavior of small chromosomes in maize
Frontiers in Plant Science, 2013 The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine and then separate at anaphase I. At anaphase II, sister chromatids separate.
James A. Birchler, Fangpu eHan
doaj +1 more source
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. [PDF]
PLoS ONE, 2009 Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis ...
William T Silkworth +3 more
doaj +1 more source
The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma
Advanced Science, EarlyView.This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan +13 more
wiley +1 more source
Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Chromosome congression and segregation in C. elegans oocytes depend on a complex of conserved proteins that forms a ring around the center of each bivalent during prometaphase; these complexes are then removed from chromosomes at anaphase onset and ...
Amanda C Davis-Roca +3 more
doaj +1 more source
Laser Microirradiation of Chinese Hamster Cells at Wavelength 365 nm [PDF]
, 1981 Cells of a V79 subline of the Chinese hamster were microirradiated at wavelength 365 nm in the presence of the psoralen derivative, trioxsalen. Microirradiation was accomplished by a pulsed argon laser microbeam either in anaphase or in interphase 3 hr ...
Berns, Michael W. +3 more
core
Advanced Science, EarlyView.Chemotherapy reduces glucose transporter expression and glucose uptake in cancer cells, leading to decreased pyruvate levels. This decline prompts ACAT1‐mediated acetylation of ME2 at Lys156, enhancing ME2 activity and promoting lactate production from glutamine.
Cuimiao Zheng +12 more
wiley +1 more source
The mitotic spindle in the one-cell C. elegans embryo is positioned with high precision and stability [PDF]
, 2016 Precise positioning of the mitotic spindle is important for specifying the plane of cell division, which in turn determines how the cytoplasmic contents are partitioned into the daughter cells, and how the daughters are positioned within the tissue. During metaphase in the early C.
arxiv +1 more source
A comparison of the distribution of actin and tubulin in the mammalian mitotic spindle as seen by indirect immunofluorescence [PDF]
, 1977 Rabbit antibodies against actin and tubulin were used in an indirect immunofluorescence study of the structure of the mitotic spindle of PtK1 cells after lysis under conditions that preserve anaphase chromosome movement. During early prophase there is no
Cande, W. Zacheus +2 more
core +5 more sources
The Anaphase-Promoting Complex [PDF]
Molecular Cell, 2002 Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and ...
openaire +3 more sources