Results 81 to 90 of about 52,438 (267)
Molecular Biology of the Cell, 2014 The mitotic apparatus protein NuMA has an intrinsic membrane-targeting mechanism that is regulated by CDK1-mediated phosphorylation, underlies anaphase-specific cortical accumulation of dynein, and contributes to chromosome separation.
Zhen Zheng +3 more
semanticscholar +1 more source
Cell Division: SACing the Anaphase Problem [PDF]
Current Biology, 2014 Errors in chromosome segregation are safeguarded by the spindle assembly checkpoint. Yet the very defects that trigger this checkpoint are inescapable consequences of sister chromatid segregation in anaphase. Three new studies provide clues to how cells cope with this problem.
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On the origins of ultra-fine anaphase bridges [PDF]
Cell Cycle, 2009 Comment on: Chan KL, Palmai-Pallag T, Ying S, Hickson ID. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol 2009; 11:753-60.
Kok-Lung Chan, Ian D. Hickson
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Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Nature Communications, 2020 Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase
Zhe Wei +3 more
doaj +1 more source
Journal of Biological Chemistry, 2014 Background: Ki67 is a widely used cell proliferation marker whose cellular functions, however, remain elusive. Results: Ki67 interacts with protein phosphatase 1γ (PP1γ) and modulates its localization in anaphase. Conclusion: Ki67 is a novel regulator of
M. Takagi +3 more
semanticscholar +1 more source
iLABMED, EarlyView.Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan +6 more
wiley +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Nature Communications, 2020 The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin
Sang-Min Jang +12 more
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The multilayer regulation of the metaphase-to-anaphase transition [PDF]
Cell Cycle, 2009 The fluctuating activity of the cyclin-dependent kinases (Cdks) is critical for the periodic phosphorylation of a given Cdk substrate. Previous studies have been focus on the positive role of Cdk-dependent protein phosphorylation in cell cycle progression.
Yanchang Wang +2 more
openaire +3 more sources