Results 71 to 80 of about 9,354,751 (270)

Diagnosis and management of ANCA-associated vasculitis.

The Lancet
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis consists of two main diseases, granulomatosis with polyangiitis and microscopic polyangiitis, and remains among the most devastating and potentially lethal forms of autoimmune inflammatory ...
A. Kronbichler, I. Bajema, A. Bruchfeld, G. Mastroianni-Kirsztajn, John H. Stone   +4 more
semanticscholar   +1 more source

Outcomes in Progressive Pulmonary Fibrosis in Systemic Autoimmune Rheumatic Diseases: Real‐World Data From the ILD‐PRO Registry

Arthritis &Rheumatology, EarlyView.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease–associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J. Bracken, Jeremy M. Weber, Megan L. Neely, Aparna C. Swaminathan, Scott M. Palmer, Erin M. Wilfong, Ann D. Chauffe, Elizabeth R. Volkmann   +7 more
wiley   +1 more source

Pathogenesis of ANCA-Associated Vasculitis, an Update

, 2011
Clinical observations, including a report of neonatal vasculitis occurring in a child born from a mother with anti-neutrophil cytoplasmic antibody directed to myeloperoxidase (MPO-ANCA)-associated vasculitis, suggest a pathogenic role for ANCA.
Cees G. M. Kallenberg, Kallenberg, Cees G. M.   +1 more
core   +1 more source

Obinutuzumab as treatment for ANCA-associated vasculitis

, 2021
International audienceAbstract Objectives Rituximab is a standard of care therapy for patients with ANCA-associated vasculitis. When rituximab is contraindicated, or in the case of refractory disease, other treatments are needed.
Langford, Carol, Amudala, Naomi, Sheridan, Brittany, Geara, Abdallah, Merkel, Peter, Cornec, Divi, Boukhlal, Sara, Brittany Sheridan, Carol A Langford, Peter A Merkel, Sara Boukhlal, Naomi A Amudala, Abdallah Geara, Divi Cornec   +13 more
core   +1 more source

The Role of Neutrophils in ANCA-Associated Vasculitis: The Pathogenic Role and Diagnostic Utility of Autoantibodies

International Journal of Molecular Sciences, 2023
Recent years have brought progress in understanding the role of the neutrophil, dispelling the dogma of homogeneous cells mainly involved in the prime defence against pathogens, shedding light on their pathogenic role in inflammatory diseases and on the ...
Agata Walulik, Kinga Łysak, Michał Błaszkiewicz, Ignacy Górecki, Krzysztof Gomułka   +4 more
semanticscholar   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

The immunopathology of ANCA-associated vasculitis [PDF]

Seminars in Immunopathology, 2014
The small-vessel vasculitides are a group of disorders characterised by variable patterns of small blood vessel inflammation producing a markedly heterogeneous clinical phenotype. While any vessel in any organ may be involved, distinct but often overlapping sets of clinical features have allowed the description of three subtypes associated with the ...
McKinney, E.F, Willcocks, L.C, Broecker, V, Smith, K.G.C   +3 more
openaire   +3 more sources

Avacopan for ANCA-associated vasculitis with hypoxic pulmonary haemorrhage

Nephrology, Dialysis and Transplantation
Background Pulmonary haemorrhage with hypoxia caused by anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has a high early mortality.
A. Chalkia, O. Flossmann, Rachel B. Jones, J. Nair, T. Simpson, Rona M. Smith, Lisa C. Willcocks, D. Jayne   +7 more
semanticscholar   +1 more source

Diagnosing and treating ANCA-associated vasculitis: an updated review for clinical practice.

Rheumatology, 2022
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of rare, primary, systemic necrotizing small-vessel vasculitides.
B. Chevet, D. Cornec, Marta Casal Moura, E. Gall, F. Fervenza, K. Warrington, U. Specks, A. Berti   +7 more
semanticscholar   +1 more source