Results 71 to 80 of about 144,883 (257)

Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young‐ and Average‐Onset Gastric Cancer

Cancer Medicine
Background There has been a paradoxical rise in young‐onset gastric cancer (YOGC), defined as gastric cancer (GC) diagnosed before age 50. Precursor lesions may contribute to pathogenesis, though their role in progression to different histologic subtypes
Patrick T. Magahis, Nicole Cornet, Laura Tang, Kanika Arora, Neha Hingorani, Stephanie King, Arnold J. Markowitz, Mark Schattner, Shoji Shimada, Steven B. Maron, Santosha Vardhana, Melissa Lumish, Andrea Cercek, Yelena Y. Janjigian, Daniel Coit, Robin B. Mendelsohn, Michael F. Berger, Vivian E. Strong, Zsofia K. Stadler, Monika Laszkowska   +19 more
doaj   +1 more source

Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally

Viruses, 2019
The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus.
Theocharis Tsoleridis, Joseph G. Chappell, Okechukwu Onianwa, Denise A. Marston, Anthony R. Fooks, Elodie Monchatre-Leroy, Gérald Umhang, Marcel A. Müller, Jan F. Drexler, Christian Drosten, Rachael E. Tarlinton, Charles P. McClure, Edward C. Holmes, Jonathan K. Ball   +13 more
doaj   +1 more source

Crossopterygian Ancestry of the Amphibia [PDF]

Science, 1913
n ...
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Concerning the Ancestry of the Dogs [PDF]

Science, 1903
n ...
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Evaluating ancestry adjustment in multi-ancestry epigenome-wide analysis

Epigenetics
Proper adjustment for population substructure is essential in epigenome-wide association studies (EWAS), particularly in cohorts with diverse ancestries.
Yueming Liu, Alan Kuang, Marie-France Hivert, William L. Lowe, Jami L. Josefson, Denise M. Scholtens   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Human genetic ancestry, Mycobacterium tuberculosis diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania

eLife
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC).
Michaela Zwyer, Zhi Ming Xu, Amanda Ross, Jerry Hella, Mohamed Sasamalo, Maxime Rotival, Hellen Charles Hiza, Liliana K Rutaihwa, Sonia Borrell, Klaus Reither, Jacques Fellay, Damien Portevin, Lluis Quintana-Murci, Sebastien Gagneux, Daniela Brites   +14 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source