Results 51 to 60 of about 144,883 (257)

Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area

Journal of Asthma and Allergy, 2022
Maria Luisa Somoza1 *, Natalia Pérez-Sánchez2 *, Isabel Torres-Rojas,1 Laura Martín-Pedraza,3 Natalia Blanca-López,1 Laura Victorio Puche,4 Eva Abel Fernández González,5 José Damián López Sánchez,6 Javier Fernández-Sánchez,7,8 Enrique Fernández ...
Somoza ML, Pérez-Sánchez N, Torres-Rojas I, Martín-Pedraza L, Blanca-López N, Victorio Puche L, Abel Fernández González E, López Sánchez JD, Fernández-Sánchez J, Fernández-Caldas E, Villalba M, Ruano FJ, Cornejo-García JA, Canto G, Blanca M   +14 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Double-Edged Nature of Whiteness for Multiracial People with White Ancestry in the US and UK

Genealogy
The privileges of Whiteness have been theorized and debated for some decades. Because White privilege has been manifested, historically, in myriad forms, it has been possible to treat the privileges of Whiteness as a given, even when its changing ...
Miri Song
doaj   +1 more source

Rethinking the 'Prejudice of Mark': Concepts of Race, Ancestry, and Genetics among Brazilian DNA Test-Takers

Revista Odeere, 2020
Sociological accounts usually emphasise the primacy of phenotype (cor, colour) over ancestry for orienting concepts of ‘race’ in Brazil. In this paper, I present an alternative account of the cultural and political significance of ancestry in ...
Sarah Abel
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Personalized nutrition: the end of the one-diet-fits-all era

Frontiers in Nutrition
Personalized Nutrition emerged as a new trend for providing nutritional and food advice based on the individual’s genetic composition, a field driven by the advancements in the multi-omic sciences throughout the last century.
Sonia Roman, Sonia Roman, Liliana Campos-Medina, Liliana Campos-Medina, Liliana Campos-Medina, Leonardo Leal-Mercado, Leonardo Leal-Mercado, Leonardo Leal-Mercado   +7 more
doaj   +1 more source

A Little Bit of That from One of Your Grandparents: Interpreting Others’ Direct-to-Consumer Genetic Ancestry Results

Genealogy, 2020
With more than 25 million tests sold by early 2019, direct-to-consumer genetic ancestry tests expose the public to critical issues of genetics, ancestry, and identity. This study examines how individuals understand the results of a genetic ancestry test.
Piotr S. Bobkowski, John C. Watson, Olushola O. Aromona   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source