Results 31 to 40 of about 144,883 (257)

Afro-Latin American Pharmacogenetics of CYP2D6, CYP2C9, and CYP2C19 in Dominicans: A Study from the RIBEF-CEIBA Consortium

Pharmaceutics
Background/Objectives: Research on pharmacogenetic variability in response to prescribed drugs and across ethnic groups is essential for personalized medicine, particularly in admixed and unstudied populations.
Mariela Guevara, Fernanda Rodrigues-Soares, Carla González de la Cruz, Fernando de Andrés, Ernesto Rodríguez, Eva Peñas-Lledó, Adrián LLerena, CEIBA Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF   +7 more
doaj   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups

Frontiers in Endocrinology
IntroductionType 2 diabetes mellitus (T2D) is a highly polygenic disease involving multiple biological pathways. Genetic ancestry may influence the predominant mechanisms driving T2D.
Ekaterina E. Markelova, Ekaterina E. Markelova, Irina V. Kononenko, Anatoliy Zubritskiy, Anatoliy Zubritskiy, Elizaveta Podshivalova, Alina Matrosova, Evgeniya Plaksina, Saleem Mansour, Pavel Ahtyamov, Pavel Ahtyamov, Elena Shagimardanova, Elena Shagimardanova, Gulnar R. Vagapova, Nadezhda Maksimova, Liubov A. Sydykova, Diana S. Avzaletdinova, Tatyana V. Morugova, Petimat M. Dzhambetova, Marina V. Shestakova, Natalia G. Mokrysheva, Yulia A. Medvedeva, Yulia A. Medvedeva   +22 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study

Genome Medicine
Background Kataegis, the focal hypermutation of single base positions in tumour genomes, has received little attention with regards to prostate cancer (PCa) molecular features, tumour evolution and associated clinical presentation.
Jue Jiang, Avraam Tapinos, Ruotian Huang, M. S. Riana Bornman, Phillip D. Stricker, Shingai B. A. Mutambirwa, David C. Wedge, Weerachai Jaratlerdsiri, Vanessa M. Hayes   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ancestry of the Timorese: Age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world

Frontiers in Genetics, 2015
We observed that the third leading cause of blindness in the world, age-related macular degeneration (AMD), occurs at a very low documented frequency in a population-based cohort from Timor-Leste. Thus, we determined a complete catalogue of the ancestry
Margaux A Morrison, Tiago R Magalhaes, Tiago R Magalhaes, Jacqueline eRamke, Silvia E Smith, Sean eEnnis, Sean eEnnis, Claire L Simpson, Laura ePortas, Laura ePortas, Federico eMurgia, Federico eMurgia, Jeeyun eAhn, Jeeyun eAhn, Caitlin eDardenne, Katie eMayne, Rosann eRobinson, Denise J Morgan, Garry eBrian, Lucy eLee, Lucy eLee, Se Joon eWoo, Se Joon eWoo, Fani eZacharaki, Evangelia E Tsironi, Joan W Miller, Ivana K Kim, Kyu Hyung ePark, Kyu Hyung ePark, Joan E Bailey-Wilson, Lindsay A Farrer, Dwight eStambolian, Margaret M DeAngelis   +32 more
doaj   +1 more source

A Non-Racial Approach to Assessing Group Membership of Victims in a Mass Grave Using Cranial Data

Forensic Sciences, 2023
In some jurisdictions, race, ancestry, or population affinity have been used for historical and po-litical, rather than biological, reasons in forensic anthropology when identifying individuals.
John Albanese, Alyssa Di Iorio
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source