Results 21 to 30 of about 144,883 (257)

Ancestry: How researchers use it and what they mean by it

Frontiers in Genetics, 2023
Background: Ancestry is often viewed as a more objective and less objectionable population descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is rapidly growing in genetics research, with ancestry groups referenced ...
Bege Dauda, Santiago J. Molina, Danielle S. Allen, Agustin Fuentes, Nayanika Ghosh, Madelyn Mauro, Benjamin M. Neale, Benjamin M. Neale, Benjamin M. Neale, Aaron Panofsky, Aaron Panofsky, Aaron Panofsky, Mashaal Sohail, Sarah R. Zhang, Anna C. F. Lewis, Anna C. F. Lewis   +15 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

Nature Communications
Prostate cancer (PCa) is highly heritable, with men of African ancestry at greatest risk and associated lethality. Lack of representation in genomic data means germline testing guidelines exclude for Africans. Established that structural variations (SVs)
Tingting Gong, Jue Jiang, Korawich Uthayopas, M. S. Riana Bornman, Kazzem Gheybi, Phillip D. Stricker, Joachim Weischenfeldt, Shingai B. A. Mutambirwa, Weerachai Jaratlerdsiri, Vanessa M. Hayes   +9 more
doaj   +1 more source

Co-constructing ancestry through direct-to-consumer genetic testing

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2021
Direct-to-consumer (DTC) genetic ancestry tests offered via the internet supposedly uncover the ancestry of those tested. While these tests might be seen as a means to find a biologically inscribed and fixed genealogy, this paper explores how companies ...
Alexander Lang, Florian Winkler
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Y chromosome variation and prostate cancer ancestral disparities

iScience
Summary: Prostate cancer (PCa) is marked by significant ancestral bias, with African men disproportionately impacted. However, genome profiling studies have yet to explore the mutational landscape and disparity contribution of the male-determining Y ...
Pamela X.Y. Soh, Alice Adams, M.S. Riana Bornman, Jue Jiang, Phillip D. Stricker, Shingai B.A. Mutambirwa, Weerachai Jaratlerdsiri, Vanessa M. Hayes   +7 more
doaj   +1 more source

Christian mission in creative tension with African worldview(s): A post-colonial engagement regarding life after death and ancestry

Missionalia: Southern African Journal of Missiology, 2016
Christian mission in African context, especially in the post-colonial era, can no longer afford to turn a blind eye to the fact that it co-exists with the African traditional religion(s).
Mashau, Derrick , Ngcobo, Themba Eric
doaj   +1 more source

Apothecial Ancestry, Evolution, and Re-Evolution in Thelebolales (Leotiomycetes, Fungi)

Biology, 2022
Closed cleistothecia-like ascomata have repeatedly evolved in non-related perithecioid and apothecioid lineages of lichenized and non-lichenized Ascomycota. The evolution of a closed, darkly pigmented ascoma that protects asci and ascospores is conceived
Luis Quijada, Neven Matočec, Ivana Kušan, Joey B. Tanney, Peter R. Johnston, Armin Mešić, Donald H. Pfister   +6 more
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

Evaluating variant pathogenicity prediction tools to establish African inclusive guidelines for germline genetic testing

Communications Medicine
Background Genetic germline testing is restricted for African patients. Lack of ancestrally relevant genomic data perpetuated by African diversity has resulted in European-biased curated clinical variant databases and pathogenic prediction guidelines ...
Kangping Zhou, Kazzem Gheybi, Pamela X. Y. Soh, Vanessa M. Hayes   +3 more
doaj   +1 more source