Results 61 to 70 of about 125,263 (264)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dynamic mechanical characteristics and engineering application of high elongation anchor cable

Meitan kexue jishu
The traditional anchor cable has low elongation, poor impact resistance, and is prone to brittle fracture failure under strong impact load, leading to roof fall, rock burst accidents and other problems in the roadway. Based on this, the anchor cable with
Yukai FU, Yongzheng WU, Penghe ZHOU, Zhuoyue SUN, Junchen LI   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Understanding the Internal Structure of Daily Activity Space from Anchor Regions: Evidence from Long-Time-Series Mobile Signaling Data

ISPRS International Journal of Geo-Information
Activity space represents the spatiotemporal interaction between individuals and their environment. While most studies measure potential activity space using short-term data, few have defined or measured its actual internal structure.
Xueyao Luo, Wenjia Zhang, Yanwei Chai, Jingxue Xie   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Capacity Of Anchors In Structural Connections

, 2013
{"references": ["S. Kokot, \"Progressive collaps - structure of industrial plastics\".\nIspra,Italy Elsevier 2012.", "B.A. Izzudin, \"Progressive collapse of mulit-storey buildings due to\nsudden column loss\". London, United Kingdom Elsevier 2007.", "A.G. Vlassis, \"Progressive collapse of multistory building due to failed\nfloor impact\".
T. Cornelius, G. Secilmis
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Investigation on stress distribution and prestress loss model of prestressed anchor cables considering corrosion-induced debonding

Rock Mechanics Bulletin
Corrosion can significantly impact the safety and stability of the entire structure by reducing the service life and load-bearing capacity of anchors. This study provides an in-depth examination of the effects of corrosion on prestressed anchor cables ...
Hanfang Zheng, Yujing Jiang, Xuezhen Wu, Sunhao Zhang, Satoshi Sugimoto   +4 more
doaj   +1 more source